1. Fever above 101F (38C) or a temperature of 96.8F (36C). 2. More than 90 heartbeats per minute. 3. More than 20 breaths per minute. 4. A probable or confirmed infection. 5. Severe muscle pain or vomiting. 6. Uncontrollable shivering. 7. Changes in skin colour (such as very cold or very flushed hands and feet) 8. Reduction in the amount of urine passed.