New treatment through drugs could end liver transplants

● Researchers in Scotland use cancer drug to help organ repair itself

A potential new liver treatment could reduce the need for transplants, Scottish scientists have found.

While the liver has the ability to repair itself this function can be lost in some injuries, including severe drug overdoses.

Liver disease is the fifth largest cause of death in the United Kingdom.

Often the damaged liver can regrow and recover, but when it suffers massive injury, regeneration may fail and even 24 hours without a fully working liver can be lifethreatening.

The study by the University of Edinburgh MRC Centre for Regenerative Medicine and the Cancer Research UK Beatson Institute in Glasgow looked at why livers lose their ability to regenerate .

They discovered that severe injuries trigger senescence throughout the liver.

Senescence is when the body’s cells age. Researchers showed severe injuries were like “contagious old age” spreading through the organ.

The team also found a chemical signal which seemed to be responsible and used an experimental cancer treatment on mice to block it.

The animals received a drug overdose that would usually lead to liver failure and death, but survived after the drugs.

Further research is needed to explore the potential of the new drugs on human patients.

Paracetamol overdose is the most common cause, with around 200 life-threatening cases in the UK annually.

Around 900 people die from liver disease in Scotland every year.

Ninety per cent of liver disease is preventable. The three commonest risk factors are excessive alcohol consumption, obesity and blood-borne viruses, in particular Hepatitisbandc.

Dr Tom Bird, liver specialist from the university, who led the study, said: “The beauty of this clinically is even if you have massive injury, if the liver is regrown then you have a normal life after that.

“Most of the patients we see with this type of critical liver injury are otherwise physically healthy, and have accidentally or, often, sadly, intentionally taken an overdose of paracetamol.

“While transplant offers incredible life-saving opportunities for these patients, it does mean a major operation and a lifetime of medication and with around 300 adults and children in the UK in need of a liver transplant at any one time, it cannot be guaranteed.”

Dr Bird added: “New treatments which set liver regeneration free and may prevent the need for liver transplants would make a huge difference for these patients.

“They may also allow us to use the livers available for transplantation for other patients with different forms of liver disease who might otherwise die whilst waiting

0 Kara Watt was admitted to intensive care with a liver malfunction

for a suitable liver donor.” The study is published in Science Translational Medicine.

Welcoming the research, Vanessa Hebditch, director of communications and policy, British Liver Trust, said: “However, this research is in the early stages and it will be a number of years before it has a direct impact on patient care.

“Further research is needed but we hope that it will lead to clinical trials with patients and that these will be successful. This would mean less people requiring a transplant.

“However, in the meantime, unfortunately once liver disease has progressed past a certain stage, transplantation is the only option.”