Bathe with wet wipes, then apply hand sanitizer to dry excess moisture.
Use a lubricant to reduce friction. Vaseline, Body Glide, and Bag Balm work, but thru-hiker Laurel “Lollygag” Reissman swears by Vagisil. “It works so well for leg chafing. It instantly stops all the pain and makes it glidey so you don’t keep wearing away skin. And it smells nice.”
Wear clothes that eliminate skin-onskin contact, such as tights.