240. Phillip Frost
$3.2 billion self-made score: * source: Pharmaceuticals age: 81 residence: Miami beach, fla. m.d., albert einstein college of medicine ’61 Frost’s Opko Health, a drug and diagnostics company that is researching treatments for Parkinson’s disease, asthma and cancer, has seen its shares plummet 34% in the last year amid slower than expected sales of an existing drug. A pioneer in the industry, Frost reformulated Key Pharmaceuticals’ asthma medicine and sold the company to Schering-plough in 1986 in an $836 million deal. One year later, he founded generic drugmaker Ivax, which was bought by Teva Pharmaceuticals for $7.6 billion in 2005.