49ers at S’hawks, 4:25
Line/OU: Seahawks by 14; 42 Once a terrific NFC West rivalry, the Seahawks have won six straight overall, and the past six matchups in Seattle, including playoffs. The Niners did little right in their home loss to Carolina as Kyle Shanahan made his debut as coach. Seattle looked bad, too, but at least it was at Lambeau Field. The Seahawks need to get the run game going after QB Russell Wilson was their top rusher with 40 yards.