Cardinals at Colts, 1
Line/OU: Cardinals by 6½; 44 Both come off rough openers. Arizona lost at Detroit and saw star RB David Johnson break his wrist. Look for WR Larry Fitzgerald to be the focal point of the offense against a weak secondary. Indy is without Andrew Luck again. Former Florida and N.C. State QB Jacoby Brissett reportedly will start. The Colts had one of the worst performances of Week 1, getting routed by the Rams.