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Best game

No. 2 Clem­son at No. 14 Bos­ton Col­lege, 6 p.m., ABC

Key matchup: The in­te­rior of Clem­son’s fierce de­fen­sive line goes against Bos­ton Col­lege’s guards and cen­ter. Dex­ter Lawrence and Chris­tian Wilkins are both pos­si­ble first-round NFL draft picks. They lead the tough­est run de­fense in the coun­try, al­low­ing 2.24 yards per carry, and a strong pass rush. Bos­ton Col­lege has three se­niors in the mid­dle of its of­fen­sive line in cen­ter Jon Baker and guards Sam Sch­mal and Chris Lind­strom, who is one of the best in the coun­try at his po­si­tion.

Facts and fig­ures: Clem­son has won seven con­sec­u­tive meet­ings … The teams play for the O’RourkeMcFad­den Tro­phy, which fea­tures a replica leather hel­met like those used by Char­lie O’Rourke of Bos­ton Col­lege and Banks McFad­den of Clem­son, when the teams played each other in the 1940 Cot­ton Bowl. … The MVP of the game also gets a black leather hel­met … Clem­son comes into the game on a tear: The Tigers have scored a school-record num­ber of points in a three-game span (177), four-game span (240), five-game span (267), six-game span (316) and seven-game span (354).

Pac-12 game of the week

No. 9 Wash­ing­ton State at Colorado, 1:30 p.m., ESPN

Key matchup: Cougars QB Gard­ner Min­shew ver­sus Colorado’s patch­work sec­ondary. Min­shew is the na­tion’s lead­ing passer. The se­nior has thrown for 3,517 yards and 27 TDs and is com­plet­ing nearly 71 per­cent of his passes, only seven of which have been picked off. He av­er­ages 52 throws a game and Colorado could be with­out SS Evan Wor­thing­ton, who missed last week’s game with a con­cus­sion he sus­tained against Ore­gon State on Oct. 27.

Facts and fig­ures: The Buffs’ four con­sec­u­tive losses in­clude two one-score set­backs . ... Colorado sopho­more CB/KR Ron­nie Black­mon had a 59-yard punt re­turn at Ari­zona last week . ... Shenault had 60 catches for 780 yards and six touch­downs when he got hurt, plus 87 yards rush­ing and five TDs on just 15 car­ries . ... The Buffs have two other in­jured WRs: Jay MacIn­tyre (con­cus­sion) and K.D. Nixon (hip), both of whom left last week’s game at Ari­zona . ... The Cougars won the matchup 28-0 last year in Pull­man.

Heis­man watch

Alabama's Tua Tago­v­ailoa has a huge lead for this year's Heis­man Tro­phy, but a pair of Big 12 quar­ter­backs can make a Novem­ber run. Ok­la­homa's Kyler Murray (3,263 to­tal yards, 38 com­bined touch­downs) and West Vir­ginia's Will Grier (2,618 pass­ing yards, 28 touch­downs) each rank in among the top five quar­ter­backs in touch­down passes. A Big 12 quar­ter­back has fin­ished in the top five in six of the last seven sea­sons, a stretch book-ended by win­ners Baker May­field (2017) and Robert Grif­fin III (2011). Big 12 quar­ter­backs pro­duce num­bers — that hasn't changed. Now, ei­ther Murray or Grier needs to win out — and they'll go head-to-head on Nov. 24 and per­haps again in the Big 12 cham­pi­onship game on Dec. 1. Murray has the big­ger spot­light this week in Bed­lam against Ok­la­homa State. For what it's worth, May­field, a three-time fi­nal­ist, never lost that game. Grier, com­ing off last week's dra­matic win against Texas, leads the Moun­taineers head­ing into a matchup against TCU.

Clem­son run­ning back Travis Eti­enne car­ries the ball dur­ing the first half against Louisville last Satur­day at Clem­son Me­mo­rial Sta­dium.JOSHUA S. KELLY/USA TO­DAY SPORTS

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