LeSean McCoy vs. Panthers nickel defense
Carolina boasts arguably the fastest linebacking corps in the NFL with the trio of Thomas Davis, Luke Kuechly and Shaq Thompson. Those three are so speedy that the Panthers stay in “regular” defensive personnel against three-receiver sets a bunch. Carolina stayed in its base 4-3 defense on 40 percent of snaps last year, fifth-most in the league. If the Panthers stay regular on passing situations, can the Bills use McCoy’s speed out of the backfield to exploit them? If the Panthers go to nickel personnel with third cornerback Captain Munnerlyn, can the Bills use McCoy to run on that grouping?