What Your Den­tist Isn't Telling You

Trillions - - In This Issue - By Robert A. Nel­son

"Drill, Fill, & Bill" has been stan­dard op­er­at­ing pro­ce­dure in den­tal prac­tice for the past cen­tury, sup­ple­mented by ex­trac­tions and dentures. In the past few decades, we have for­tu­nately gained the ben­e­fits of such novel won­der­ments as im­plants, restora­tions, in­vis­i­ble braces, mer­cury-free fill­ings, and teeth whiten­ing.

Dozens more tech­nolo­gies presently un­der de­vel­op­ment prom­ise to elim­i­nate bad breath, pre­vent cav­i­ties, re­store teeth with ap­pli­ca­tions of min­eral for­mu­las, or even to grow new teeth from stem cells.

If, how­ever, you were to ask your den­tist about any of these in­ven­tions, it is a very safe bet that he or she would plead ig­no­rance. Be­ing bur­dened with debt while try­ing to get a life, few prac­ti­tion­ers have the time to do re­search.

Don't hold your hal­i­to­sis wait­ing for such mar­vels to be­come avail­able. The te­dious and costly process of dis­cov­ery, de­vel­op­ment, safety test­ing, govern­ment ap­proval, and mar­ket­ing can take twenty years or more. For ex­am­ple, scores of patents have been granted since the 1980s for var­i­ous for­mu­la­tions that in­cor­po­rate sodium py­rophos­phate to dis­solve the plaque that plagues our mouths. It did not be­come an in­gre­di­ent in tooth­paste un­til 2017.

Plaque

Pro­fes­sor Alexan­der Rickard, et al. (Univ. of Michi­gan) dis­cov­ered that the amino acid l-argi­nine also desta­bi­lizes the biofilms that even­tu­ally morph into plaque, cav­i­ties, and pe­ri­odon­tal dis­ease. Argi­nine al­ready is be­ing used in some den­tal prod­ucts for tooth sen­si­tiv­ity. If you can't wait for his US Patent Ap­pli­ca­tion 2011236508 to be­come a prod­uct, you can buy argi­nine on­line at ebay and do it your­self.

Fu­ture plaque for­ma­tion and stains can be pre­vented by a prod­uct called KISSCARE. It is a non-stick sil­i­cone den­tal coat­ing seals and pro­tects teeth and dentures for up to six months. Ap­ply it with a swab or floss after hav­ing your teeth cleaned. KISSCARE is avail­able from WDR Sci­en­tific..

Rem­iner­al­iza­tion

Rem­iner­al­iza­tion tooth­paste reached the mar­ket­place sev­eral years ago as No­vamin, which uses cal­cium-sodium phos­pho­sil­i­cate bio­glass to build a shell to pro­tect teeth from fur­ther de­cay. Glax­osmithk­line bought No­vamin for $135 mil­lion in 2010. It is cur­rently man­u­fac­tured by GSK in the UK un­der the Sen­so­dyne la­bel, but for un­known rea­sons, it is not avail­able in the USA.

Dr Kazue Ya­m­ag­ishi and her col­leagues at the FAP Den­tal In­sti­tute, Tokyo, have de­vel­oped a tooth­paste for­mula of hy­drox­ya­p­atite, hy­dro­gen per­ox­ide, and cal­cium phos­phate which in­te­grates with nat­u­ral enamel to nat­u­rally re­fill cav­i­ties. In De­cem­ber 2016, Dr Ya­m­ag­ishi has an­nounced that, "De­spite hav­ing suc­cess­fully pro­duced our tooth­paste in small quan­ti­ties, we have faced some dif­fi­cul­ties dur­ing mass-pro­duc­tion due to the fact that the pro­ce­dure re­quires more time than ex­pected. There­fore, we would like to kindly ask you for your pa­tience un­til we are able to com­plete the pro­duc­tion."

If you can't wait, you can to make your own by us­ing the de­scrip­tion given in her US Patent Ap­pli­ca­tion US2005123490 ("Com­po­si­tion and Method for Pre­ven­tion and Treat­ment of Den­tal Caries").

An­other way to fight pe­ri­odon­tal bone loss is de­scribed in Ja­panese patent JPH08133969 ("Alve­o­lar Bone Re­sorp­tion In­hibitor"): "This in­hibitor con­tains cal­cium pan­tothate [ 0.001-20wt.% ]... The in­hibitor has ex­cel­lent ac­tion to in­hibit alve­o­lar bone re­sorp­tion caused by the en­do­toxin of bac­te­ria such as Por­phy­romonas gin­gi­valis or Acti­nobacil­lus acti­no­mycetem­comi­tans as a ma­jor cause of the pe­ri­odon­tal dis­eases".

Pro­fes­sor Nigel Pitts (Den­tal In­sti­tute, King’s Col­lege, Lon­don) has per­fected a method of "Elec­tri­cally Ac­cel­er­ated and En­hanced Rem­iner­al­i­sa­tion" us­ing ul­tra­sound-driven ion­tophore­sis to trans­port min­er­als into teeth to re­pair enamel.

Prof. Pitts says, “The way we treat teeth to­day is not ideal – when we re­pair a tooth by putting in a fill­ing, that tooth en­ters a cy­cle of drilling and re-fill­ing as, ul­ti­mately, each “re­pair” fails.

“Not only is our de­vice kin­der to the pa­tient and bet­ter for their teeth, but it’s ex­pected to be at least as cost-ef­fec­tive as cur­rent den­tal treat­ments. Along with fight­ing tooth de­cay, our de­vice can also be used to whiten teeth.” ...

A firm called Remi­nova has been es­tab­lished in Perth, Scot­land, to mar­ket the treat­ment.

Dr Gerard Judd takes a much sim­pler ap­proach to the prob­lem of restor­ing enamel and pre­vent­ing its loss. He ad­vises us to brush the teeth with bar soap and to take daily sup­ple­ments of cal­cium and vitamin D, plus monosodium phos­phate. He ex­plains his reg­i­men in a free on­line book, "Good Teeth From Birth To Death" :

"Monosodium phos­phate is the best sup­ple­ment for phos­phate since it is very pure and highly sol­u­ble in wa­ter. Sim­ply take about 1/5 tea­spoon (1 gram), dis­solve it in 1 inch of wa­ter in less than a minute, then fill up the glass and drink it daily. This takes care of all the bones, teeth, DNA, RNA and at least 30 phos­phate-con­tain­ing en­zymes..."

"To make teeth clean one brushes with any bar soap. Soap washes off in just 2 rinses. What about tooth­pastes? Glyc­er­ine in all tooth pastes is so sticky that it takes 27 washes to get it off. Teeth brushed with any tooth­paste are coated with a film and can­not prop­erly reenamelize... [ Plaque ] is pre­vented and even­tu­ally re­moved by brush­ing with bar soap.

"Tak­ing cal­cium and phos­phate in the diet re­sults in reenameliza­tion of the teeth, but only when they are clean. Bar soap does a per­fect job in clean­ing the sur­face..."

Ob­vi­ously, if you choose take Dr Judd's ad­vice, use soap that does not con­tain glyc­er­ine.

Nanobub­bles

When Don Ho, Wayne New­ton, and other croon­ers sang the praises of "Tiny Bub­bles" in the 1960s, nan­otech­nol­ogy did not yet ex­ist. Fifty years later, the song has been vin­di­cated by nanobub­bles, which pos­sess unique prop­er­ties with tremen­dous po­ten­tial ap­pli­ca­tions. Fresh­wa­ter and salt­wa­ter fish can live to­gether in it. Nanobub­ble wa­ter is 70% ef­fec­tive against can­cer. It pu­ri­fies wa­ter. And it treats gin­givi­tis.

Jeng Soo Choi was granted USP 8821160 ("Nano Bub­ble Gen­er­at­ing Noz­zle and Oral Clean­ing De­vice"). Sim­i­larly, Yoshiro Mano's US Patent Ap­pli­ca­tion 20100151043 ("Prepa­ra­tion for Ster­il­iza­tion or Dis­in­fec­tion of Tis­sue") uses nanobub­bles wa­ter "for ther­a­peu­tic or pro­phy­lac­tic treat­ment of a pe­ri­odon­tal dis­ease". It's any­body's guess as to when it will be­come avail­able to the unlavaged pub­lic.

Ozone

Den­tal ozone was pi­o­neered by Pro­fes­sor Ed­ward Lynch (Queen's Den­tal Hos­pi­tal and Belfast Univer­sity, Ire­land). Since it was in­tro­duced in 1998, ozone has proven it­self to be ex­tremely ef­fec­tive non-de­struc­tive method of den­tal prac­tice. A 60-se­cond treat­ment de­stroys all bac­te­ria in the vicin­ity. It is a sim­ple, quick, non­in­va­sive, and pain­less pro­ce­dure that saves time and money, and greatly re­duces pa­tients' anx­i­ety. The ef­fi­cacy of the Healo­zone Den­tal Den­tal De­vice, which is man­u­fac­tured in Ger­many, has been con­firmed by sev­eral clin­i­cal stud­ies.

Ex­ten­sive bib­li­ogra­phies and down­load­able re­search re­ports on the sub­ject of ozone den­tistry are avail­able on­line at http://www.den­talo­zone.co.uk and http://www.kavo.com . These patents also per­tain : US6409508, US7172426, US2003143164, US6773610, US2005112525, US6267895, US2002127158, US5824243, US2002134736, DE19932570, DE3324939, WO2006014080, WO2005032393, WO02078663, WO02078644, WO9965533, WO9953966, WO9742924, WO9306948, WO02066079, EP0988834, EP1372572, JP9201374, JP3186257, JP2252460, JP1181869, JP63292961, JP63281656, JP63281655, JP 62047355, JP 11137580, JP 9000548, JP 2002253582, JP 2002248116, CN1594137, CN2707208, CN1778395, and KR 2004008011. They are avail­able from that awe­some ma­ter­nity ward of in­ven­tion known as the Euro­pean Patent Of­fice .

A sim­i­lar ap­proach has been de­vel­oped by Pro­fes­sors Chunqi Jiang and Par­ish Sedghizadeh (Univ. So. Cal.). 100 nanosec­ond pulses per mil­lisec­ond with non-ther­mal, room tem­per­a­ture plasma of atomic oxy­gen in­stantly dis­rupts den­tal biofilms. Their patent ap­pli­ca­tion US2009143718 ("Plasma Treat­ment Probe") re­mains pend­ing after 8 years, so don't ex­pect to find it in your mouth any time soon un­less you want to vol­un­teer as a test sub­ject.

The "Plasma Den­tal Brush", in­vented by Qing­song Yu, et al. (Univ. Mis­souri), has been de­vel­oped by Nanova, Inc. A news re­lease in 2011 stated that it could be avail­able to den­tists "as early as 2013". It was fi­nally in­tro­duced at IDS 2017, where Nanova's An­drew Ritts de­scribed the in­stru­ment as "a low tem­per­a­ture non-equi­lib­rium ar­gon plasma that pain­lessly cleans and mod­i­fies the sur­face of teeth and im­proves bond­ing of fill­ings".

Hal­i­to­sis

Stink Breath is caused by the gaseous emis­sions of the count­less bac­te­ria breed­ing in our maws, some of which are harm­less, while other strains are prob­lem­atic.

Mouth­wash has only a small, brief ef­fect against hal­i­to­sis. In the con­sid­ered opin­ion of An­drea Az­carate-peril (Di­rec­tor, Mi­cro­biome Re­search Core, Univer­sity of North Carolina), "An­tibac­te­rial mouth­washes are be­ing overused to the point where they could be do­ing more harm than good. We are just too clean," she said.

In­stead of killing bac­te­ria with chem­i­cals, John Tagg, et al., have ex­ploited the pro­bi­otic ef­fect of be­nign Strep­to­coc­cus sali­var­ius K12, one of the many denizens of our mouths. The K12 strain is used to re­pop­u­late the tongue sur­face and thus pre­vent the re-es­tab­lish­ment of un­de­sir­able oc­cu­pants. Tagg con­cludes that "pro­bi­otic bac­te­rial strains orig­i­nally sourced from the indige­nous oral mi­cro­bio­tas of healthy hu­mans may have po­ten­tial ap­pli­ca­tion as ad­juncts for the pre­ven­tion and treat­ment of hal­i­to­sis." Some­day, per­haps...

Other re­searchers have in­vented vac­cines and an­ti­bod­ies against the var­i­ous bac­te­ria which cause pe­ri­odon­tal dis­ease :

Patent WO2010107120 ("An­ti­body and Anti-pe­ri­odon­tal Dis­ease Com­po­si­tion Con­tain­ing An­ti­body") de­scribes "a chicken egg an­ti­body, which is ob­tained from an avian egg hav­ing been im­mu­nized with an anti­gen that is a cul­ture ob­tained by mixed-cul­tur­ing two or more kinds of pe­ri­odon­tal bac­te­ria, is used as an anti-pe­ri­odon­tal dis­ease com­po­si­tion. The pe­ri­odon­tal bac­te­ria prefer­ably com­prise two or more kinds of bac­te­ria se­lected from among Por­phy­romonas gin­gi­valis, Fu­sobac­terium nu­clea­tum, Acti­nobacil­lus acti­no­mycetem­comi­tans, Tan­nerella forsythen­sis, Tre­ponema den­ti­cola, Prevotella intermedia and Strep­to­coc­cus gor­donii."

USP 4454109 ("Method of Treat­ing Pe­ri­odon­to­sis") treats pa­tients with an in­hibitory amount of an ef­fec­tor strain of Strep­to­coc­cus san­guis, Strep. uberis or Acti­no­myces bo­vis.

USP 4661350 ("Den­tal Vac­cine for In­hibit­ing Pe­ri­odon­ti­tis") was granted for anti­gens iso­lated from the pili of Acti­no­myces vis­co­sus, Act. naes­lundii, Act. acti­no­mycem comi­tans, and Bac­teroides gin­gi­valus.

Ja­panese patent JP2005306890 ("Method for Mod­er­at­ing En­do­toxin of Pe­ri­odon­tal Dis­ease") uti­lizes lacto­fer­rin-re­lated pro­teins and amino acids to sup­press ad­he­sion of Acti­nobacil­lus acti­no­mycetem­comi­tans, Por­phy­romonas gin­gi­valis, and Fu­sobac­terium nu­clea­tum, etc.

Sim­i­lar meth­ods are de­scribed in JP2005306890, JP2006131542, JP2006131542, JP3389556, JPH08176014, JPH04217626, JPH05132428, JPH0952846, JPH0952822, JPH0640869, CA1195613, DE4324859, EP1508335, etc.

Herbs

Ap­prox­i­mately 2,000 years ago, and prob­a­bly much ear­lier, the people of Su­dan ate the bit­ter tu­bers of Pur­ple Nutsedge . When ar­chae­ol­o­gists an­a­lyzed the plaque on the teeth of skele­tons in an an­cient ceme­tery called Al Khi­day 2, they found that fewer than 1% had cav­i­ties or any other signs of de­cay, thanks to the an­tibac­te­rial prop­er­ties of the weed.

Stephen Buck­ley, et al., re­ported in the jour­nal PLOS ONE that "This plant is a good source of car­bo­hy­drates and has many use­ful medic­i­nal and aro­matic qual­i­ties, though to­day it is con­sid­ered to be the world's most costly weed. Its abil­ity to in­hibit Strep­to­coc­cus mu­tans may have con­trib­uted to the un­ex­pect­edly low level of caries found in the agri­cul­tural pop­u­la­tion."

Many herbs are used as breath sweet­en­ers, and some also are ef­fec­tive against the causative bac­te­ria. Dozens of tra­di­tional Chi­nese for­mu­la­tions in­clude ex­tacts of such plants, e.g. :

Choco­late snake­root, pur­ple gi­ant hys­sop, an­gel­ica, hon­ey­suckle, hawthorn, licorice, mint, mul­berry leaves, dan­de­lion, ag­ri­mony, rehman­nia root, bit­ter or­ange, lo­quat leaf, areca peel, mag­no­lia bark, lo­tus leaves, nut­meg, ginger, clove, cin­na­mon, gin­seng, green­briar roots, kudzu flow­ers, Chi­nese per­fume plant, kadsura stems, cinque­foil, or­ange peel, Enok­i­take mush­room, Shen Nong’s Her­bal, wild ginger, co­hosh, Dahurian an­gel­ica, bal­loon flower root, ar­row­root, Ja­panese raisin tree, ju­jube, ginkgo leaves, gar­de­nia, skull­cap, prairie turnip, white tum­ble­weed, false daisy, pe­ony, and Chi­nese prickly ash.

Dr. Robert O. Nara, D.D.S., pro­motes nat­u­ral pre­ven­tive care, and es­pe­cially rec­om­mends the use of hyaluronic acid to pro­tect and re­store gums. He also of­fers Pe­ri­o­cleans Oral Cleans­ing Con­cen­trate for brush­ing and rins­ing. It con­tains ex­tracts of echi­nacea pur- purea, cal­en­dula, olive leaf, black wal­nut hulls, gotu kola, chamomile, blood root, green tea leaf, prickly ash bark, grape­fruit seed, oils of pep­per­mint, oregano, clove, thyme, folic acid, Coen­zyme-q10, aloe vera, and chloro­phyll.

Wait, there's more ! A patent-search yields about 100 treat­ments for py­or­rhea, AKA pe­ri­odon­ti­tis, the pu­ru­lent in­flam­ma­tion of gums and alve­o­lar pock­ets. The in­gre­di­ents listed in those patents in­clude the fol­low­ing veg­etable sub­stances, vi­ta­mins and min­er­als which are gen­er­ally rec­og­nized as safe for un­pre­scribed use:

Dried old or­ange peel, com­mon rush, genus Thu­jop­sis of the fam­ily cy­press, methyl sal­i­cy­late, L- men­thol, shel­lac, hi­noki­tiol, pine, li­lac leaves, saf­flower ex­tract, cal­cium hy­dro­gen­phos­phate an­hy­drous salt (min­eral name mon­etite), rock salt, cal­cium sul­fate, hy­drox­ya­p­atite, ascor­bic acid or sodium ascor­bate, vitamin E, vitamin B6, gly­cyrrhizin, hi­noki­tiol, pa­pain, sodium bi­car­bon­ate, zinc ox­ide, ti­ta­nium diox­ide, Su­per­ox­ide dis­mu­tase, tau­rine, bi­va­lent iron salt, egg white lsozyme, hy­drox­ya­p­atite, green tea, black roasted egg­plant, ac­tive car­bon, povi­done-io­dine & potas­sium io­dide, propo­lis, globe­flower, and for­sythia fruit.

Elec­tro-den­tistry

Elec­trol­y­sis has been used ex­per­i­men­tally in var­i­ous den­tal ap­pli­ca­tions since the 1930s. The May 1932 is­sue of Modern Mechanix Mag­a­zine pro­claimed, "Have Your Next Tooth Filled Elec­tri­cally!", yet sev­eral hu­man gen­er­a­tions later, that hope­ful prom­ise re­mains un­ful­filled, and cav­i­ties are still be­ing packed with amal­gams.

An­other vari­a­tion of elec­tro-den­tistry is de­scribed in Chi­nese patent CN1054188 ("Elec­tronic Method and Im­ple­ment for Clean­ing Teeth"), ac­cord­ing to which, "Two elec­trodes are con­nected to a DC power sup­ply for elec­trolytic clean­ing. The den­tal pro­tein de­posit bear­ing pos­i­tive charge is sep­a­rated from the teeth. The mu­cosa of den­tal de­posit is dis­solved in wa­ter. The cal­cium in odon­tolith of cal­cium lac­tate is educed out from neg­a­tive elec­trode. Thus, the teeth or ar­ti­fi­cial teeth are cleaned safely and ef­fec­tively and the den­tal pe­riph­ery is cleaned in large area. The im­ple­ment in­cludes pe­ri­odon­tal cleaner, ar­ti­fi­cial teeth cleaner, etc."

Ja­panese patent JP2010275287 ("Method for Pre­vent­ing Dis­ease in Oral Cav­ity") elec­tri­cally ap­plies ac­tive car­bon be­tween gums and teeth to pro­tect them from gin­giva.

US Patent 8652645 ("Os­teosyn­the­sis with Nano-sil­ver") ap­plies a coat­ing of sil­ver and ti­ta­nium ox­ide by plasma elec­trolytic ox­i­da­tion. The patent claims that "an AG-TIO2 coat­ing shows ex­cel­lent prop­er­ties in terms of an­tibac­te­rial ef­fi­cacy (even against multi-re­sis­tant strains), ad­he­sion and bio­com­pat­i­bil­ity. The life-time of an im­plant in a hu­man body is in­creased."

Re­lated patents in­clude US3019787 ("Ap­pa­ra­tus for Elec­trolytic Den­tal De­sen­si­ti­za­tion"), US4495045 ("Elec­trolytic Den­tal Etch­ing Ap­pa­ra­tus"), and IT1251515 (Elec­trolytic Ster­il­i­sa­tion of In­fected Root Canals).

Be­gin­ning work in 1975, Zeev Davi­dovitch and Ed­ward Korostoff ( Univ. Penn­syl­va­nia) used elec­tri­cal stim­u­la­tion to ac­cel­er­ate the mi­gra­tion of bone tis­sue by about 50%, thereby re­duc­ing the time re­quired to wear braces. A 3-year clin­i­cal study with 60 pa­tients be­gan in 1980. Fast for­ward to 2017, and the method is not yet in use. See US Patent 4153060 ("Method and Ap­pa­ra­tus for Elec­tri­cally En­hanced Bone Growth and Tooth Move­ment") for the tech­ni­cal de­tails.

Tooth Re­gen­er­a­tion

By the time one reaches the age of 50, odds are that you have lost an av­er­age of 12 teeth out of 32 and now sport dentures or im­plants. The even­tual fu­ture prom­ises that "soon" we will be able to grow new teeth from stem cells on bone scaf­folds, thanks to en­cour­ag­ing re­search in progress.

Paul Sharpe, a spe­cial­ist in re­gen­er­a­tive den­tistry (Den­tal In­sti­tute of King's Col­lege, Lon­don), has de­vel­oped a new pro­ce­dure whereby stem cells are cul­ti­vated to form a bud which is in­serted in the socket of a miss­ing tooth. Within a few months, it ma­tures into a fully formed tooth. Sharpe and his team set up a com­pany, Odon­tis, to ex­ploit the tech­nol­ogy, and re­ceived £400,000 fund­ing from the Na­tional En­dow­ment for Sci­ence, Tech­nol­ogy and the Arts and the Well­come Trust, but noth­ing more has emerged from their lab since 2004. Tech­ni­cal de­tails of the method are de­scribed in Sharpe's patents : WO2006024856 ("Jaw Bone Aug­men­ta­tion us­ing Tooth Pri­mordium"), US7588936 ("Gen­er­at­ing Teeth from Bone Mar­row cells"), and US7497686 ("Bone Re­gen­er­a­tion").

Pro­fes­sor Jeremy Mao, et al. (Columbia Univer­sity Med­i­cal Cen­ter), also are de­vel­op­ing a sim­i­lar method, whereby the pa­tient's so­matic cells are col­lected and re­pro­grammed to gen­er­ate a pa­tient-spe­cific IPS cell line. These are cul­tured to pro­duce ameloblasts, odon­to­blasts, ce­men­to­blast and pulp cells which are re­com­bined and trans­planted onto a scaf­fold where it grows into a com­plete tooth in about nine weeks. The tech­nique is patent pend­ing ( US2014302111, "Com­po­si­tions and Meth­ods for Den­tal Tis­sue Re­gen­er­a­tion"; US2014093481, "Pro­duc­tion of Dentin, Ce­men­tum, and Enamel by Cells"; US2013022989, " Den­tal Stem Cell Pro­gram­ming", and US2011236977, "Den­tal Stem Cell Dif­fer­en­ti­a­tion", etc.).

Ståle Lyn­gstadaas and his col­leagues at the Univer­sity of Oslo also prom­ise to rev­o­lu­tion­ize den­tal surgery with their next-gen­er­a­tion ti­ta­nium ox­ide scaf­fold :

"With our new method, it’s suf­fi­cient to insert a small piece of syn­thetic bone-stim­u­lat­ing ma­te­rial into the bone. The ar­ti­fi­cial scaf­fold­ing is as strong as real bone and yet por­ous enough for bone tis­sue and blood ves­sels to grow into it and work as a re­in­force­ment for the new bone...

"A lot of empty space is im­por­tant. The cav­i­ties are suf­fi­ciently large to make space not only for bone cells, but also for blood ves­sels that can bring in nutri­ents and oxy­gen and re­move waste prod­ucts. One of the big prob­lems with cur­rent ma­te­ri­als is that they do not pro­vide space for both bone tis­sue and blood ves­sels."

The tech­nol­ogy is un­der de­vel­op­ment by Cor­ti­calis, which also pro­duces "Nugel" to com­bat peri-im­plan­ti­tis, a site-spe­cific in­fec­tious dis­ease that causes in­flam­ma­tion in soft tis­sues, and bone loss around im­plants. Ac­cord­ing to the Cor­ti­calis web­site, "Nugel is a gel that de­brides im­planted im­plants on a nano-level. It ef­fec­tively re­moves sub­stan­tially all of the bac­te­ria caus­ing peri-im­plan­tis and thus greatly re­duce the risk of peri-im­plan­tis due to bac­te­ria. In ad­di­tion to this, Nugel has an anti-in­flam­ma­tory ef­fect."

As de­scribed in the ab­stract of Cor­ti­calis' patent ap­pli­ca­tion (US2013115248, "De­bride­ment Paste"), the in­ven­tion "com­prises op­ti­mally ac­ti­vated nanopar­ti­cles of TIO2, hav­ing a mean par­ti­cle di­am­e­ter (D50) of about 10-100 nm at a con­cen­tra­tion be­tween 0.5500g/l, and H2O2, at a con­cen­tra­tion of at the most 7.5% by vol­ume, said com­po­si­tion be­ing an­tibac­te­rial, with­out caus­ing mi­cro­bial re­sis­tance, and anti-in­flam­ma­tory, and wherein said com­po­si­tion fur­ther com­prises solid mi­cropar­ti­cles, hav­ing a mean par­ti­cle di­am­e­ter (D50) of about 100-200 wm at a con­cen­tra­tion be­tween 0.5-300 g/l, for im­proved me­chan­i­cal de­bride­ment and/or clean­ing of rough sur­faces in the oral cav­ity and/or on an im­plant."

In clos­ing this review, I would like to sug­gest that you print a copy to give to your den­tist the next time you have an ap­point­ment. It will make for in­ter­est­ing con­ver­sa­tion un­til your tongue goes numb with anes­the­sia, and it might mo­ti­vate the doc­tor to in­ves­ti­gate and in­vest in an den­tal ozone de­vice or some other prod­uct de­scribed here.

For more in­for­ma­tion they don't want you to know please visit www.rexre­search.com.

About the Au­thor : Robert A. Nel­son is a 10th grade dropout with no cre­den­tials. He es­tab­lished Rex Re­search in 1982 to archive and dis­sem­i­nate in­for­ma­tion about sup­pressed, dor­mant, and emerg­ing tech­nolo­gies, and per­sists at the seem­ingly fu­tile ef­fort to this day.

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