Lac­tate may pro­tect di­a­bet­ics against com­pli­ca­tions of hy­po­glycemia

Wellness Update - - Health News -

NEW HAVEN, Conn. – Pro­vid­ing the brain with lac­tate and po­ten­tially other fu­els may pro­tect di­a­bet­ics against life-threat­en­ing bouts of hy­po­glycemia, a Yale study has found. Both type 1 and type 2 di­a­bet­ics must tightly con­trol their blood glu­cose lev­els to pre­vent long-term com­pli­ca­tions of the dis­ease. But the in­ten­sive daily reg­i­men of in­sulin that is re­quired may of­ten re­sult in se­vere episodes of hy­po­glycemia, or dan­ger­ously low blood sugar lev­els. Such episodes may oc­cur with­out warn­ing or dur­ing sleep, and can lead to brain dam­age, cog­ni­tive im­pair­ment, or even death. The Yale team in­ves­ti­gated al­ter­nates to glu­cose as fuel sources for the brain to find out if they can help di­a­bet­ics achieve the nec­es­sary tight glycemic con­trol. They in­fused ro­dents with lac­tate and mea­sured lev­els of in­dica­tive chem­i­cals in their brains. Their re­sults show that lac­tate helped the an­i­mals main­tain nor­mal lev­els of glu­cose dur­ing bouts of hy­po­glycemia, and helped re­verse symp­toms as­so­ci­ated with acute hy­po­glycemic at­tacks. There may be im­pli­ca­tions in this study for hu­man di­a­bet­ics. “Our find­ings help us un­der­stand how brain en­ergy

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