Is it pos­si­ble that be­ing de­fi­cient in Vi­ta­min D has any­thing to do with in­creased dis­ease ac­tiv­ity and ex­treme fa­tigue? Me­dia, PA

Wellness Update - - Fatigue And Lupus -

Good ques­tion and one which our group has been re­search­ing for sev­eral years, since find­ing that a ma­jor­ity of pa­tients with lu­pus have low blood lev­els of vi­ta­min D. Th­ese low lev­els are likely due to sev­eral causes, one of which is sun-avoid­ance since di­rect sun­light is a trig­ger of lu­pus flares but it is also our main source of vi­ta­min D. We know that ad­e­quate vi­ta­min D is im­por­tant for bone health as well as bal­ance/sta­bil­ity and we are still learn­ing about the ways vi­ta­min D in­flu­ences im­mune sys­tem health. Dr. Guillermo Ruiz-Iras­torza and his group in Spain stud­ied the re­la­tion­ship be­tween fa­tigue mea­sure­ments in pa­tients with lu­pus and their blood 25-hy­drox­yvi­ta­min D lev­els and con­cluded that very low vi­ta­min D lev­els pre­dicted higher fa­tigue scores. When vi­ta­min D lev­els were in­creased by oral vi­ta­min D3 sup­ple­ments, fa­tigue among the pa­tients im­proved. This is promis­ing news that vi­ta­min D sup­ple­men­ta­tion for those pa­tients who are vi­ta­min D de­fi­cient may help with fa­tigue and sev­eral re­search stud­ies of vi­ta­min D are un­der­way for us to learn more.

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