When the Chances Increase
Currently, the Ministry of Health is considering further improving the development of the hematology service. In particular, we are talking about the transformation of the Research Institute of Hematology and Blood Transfusion into a specialized Republican Specialized Scientific and Practical Medical Center.
“The reorganization of our medical institution should be a logical continuation of the work carried out here on the introduction of modern high-tech methods of diagnosis and treatment,” said Professor Hamid Karimov, head of the Center for Bone Marrow Transplantation. «This will allow us to introduce a mixed type of financing for these methods of treatment, similar to what is being used today at the Vahidov Center for Surgery, Cardiology and other medical institutions that have the same status. That is to say, that part of the cost of such treatment will be covered by budgetary funds, and the other - at the expense of personal funds of patients. As a result, all existing barriers will be eliminated for the timely receipt of treatment by patients, without leaving the republic.”
Our regular meeting with Professor Hamid Karimov began with these words. In accordance with the editorial assignment within the framework of this meeting, the correspondents were to talk about the introduction and application by specialists of the Research Institute of Hematology and Blood Transfusion of all innovations in the diagnosis and treatment of malignant neoplasms of lymphatic and haematopoietic tissue (hemoblastoses). These are the most common tumor diseases, in other words all of what we have been talking about over the past few years in our materials on the activities of the Institute.
Experts note that over the past 20 years, thanks to the development and implementation of high-tech molecular biological technologies, a real revolution has taken place in the world medical practice, which made it possible to deduce a significant part of hemoblastoses from the category of “fatal” diseases. That is why the development of molecular medicine largely determines the level of the entire medicine of the country. In recent years, the Center for Transplantation of Stem Cells from the Bone Marrow has been established at the Research Institute of Hematology and Blood Transfusion, equipped with modern high-tech laboratory and medical equipment, which makes it possible to carry out the necessary diagnostics and treatment at the highest technological level using all advanced technologies.
- About ten years ago, our institute for the first time in the republic, with the help of the charitable program of the company Novartis Pharma (Switzerland), began to apply methods of treatment with drugs that selectively affect specific gene mutations (molecular-targeted therapy). This was a revolutionary breakthrough in the field of targeted antitumor therapy of certain types of leukemia. Thanks to the charity program of this company, our patients have the opportunity to receive these expensive medicines for free. At the same time, the company puts only one condition for starting such a treatment - it is necessary to provide the results of laboratory studies, according to which it becomes clear that the provided drugs “Glivec” and “Tasigna» can really help the patient. The fact is that they are effective only for specific forms of the disease, - says Khamid Yakubovich. “However, in the early years before the completion of equipping our laboratory with modern, expensive equipment in 2014, the number of patients who took advantage of this opportunity was small. The reason is that for the necessary diagnostics they were forced to travel to Russia and other countries, which required financial costs. Today, all the necessary tests are performed in our institute, and the number of those who receive these medicines has already reached almost a thousand. The total amount of donated aid to Novartis Pharma amounted to more than $ 115 million and over 8 million Swiss francs. At the same time, I particularly want to emphasize that we work on certified devices manufactured by leading companies in Europe and the US, and surveys are conducted by specialists who have completed long internship and retraining courses at leading foreign centers in Germany, the Czech Republic, Turkey, Russia, Japan and other countries.
To date, the Institute has successfully introduced a new molecular-biological technology for the examination of patients and a comprehensive 4-level diagnosis and monitoring of leukemia therapy according to the international IS scale (i.e. at the genomic, genomic, chromosomal levels and at the level of the CD-cell receptors) . To date, more than 7,500 studies have been performed using this technology. The diagnostic and predictive effectiveness of this technology in the format of the international IS scale reaches up to 99.9%. Most importantly, thanks to these new developments, it became possible to introduce into the clinical practice two high-tech methods for treating hemoblastoses, which allow achieving remission and complete recovery in 7095% of patients.
Another innovation, applied at the Institute, is the treatment of patients with their own hematopoietic stem cells. To date, more than 200 patients with myeloma have undergone standard chemotherapy, and 23 patients with myeloma and 2 with lymphoma have successfully made high-tech therapy with their own stem cells for the first time in Central Asia. To date, there is the issue of expanding the practice of using stem cell therapy. Hamid Karimov emphasized, that the reorganization of the institute and introduction of mixed forms of financing of high-tech methods of treatment can contribute to solve this task.
The total financial savings from all implementations in the Institute amounted to more than $117 million, 3 million euros and 8 million Swiss francs. But most importantly, the chances for recovery of the patients increased, many cured patients gained the opportunity for a full life, started a family and continued their work activities.
- All these implementations were due to financial support of the Institute's projects, the sources of which included the State Investment Program, grant and extrabudgetary funds of the Institute, humanitarian assistance from the Turkish Cooperation and Coordination Agency (TICA) under the Prime Minister's Office of Turkey and the international JIPAP program- noted Professor Hamid Karimov.
The Institute has trained personnel and created a material and technical base for carrying out not only transplantation of stem cells, but also other organs and tissues. In addition to the expected reorganization of the institute, other measures are planned to strengthen the material and technical base of the institute and ensure uninterrupted provision of necessary consumables. This allows for more full-scale introduction of stem cell allotransplantation and other high-tech methods of diagnostics and treatment into clinical practice. Among other things, the issue of assigning the status of the “Reference Center” for the HLA genotyping to the Center for Molecular Medicine and Cell Technology is also under consideration given the level of equipment with the necessary equipment, the material and technical base and the preparedness of the staff.
It is noteworthy that by now the Center has become the largest research and development unit that carried out works to introduce and develop new high-tech diagnostic and treatment methods that rise hope to recover more patients. To date, more than 25 joint research projects have been carried out here on the basis of bilateral agreements with many leading republican medical institutions, such as Tashkent Medical Academy (Department of Neurology, Obstetrics and Gynecology, Departmental and Hospital Therapy), Tashkent Pediatric Medical Institute, Tashkent Institute of Advanced Medical Education, Tashkent Dental Institute, Republican Pediatric Institute, Ministry of Health of Uzbekistan, medical institutes of Samarkand, Bukhara, Andijan, Khorezm, Republican Specialized Scientific-practical Medical Center of Dermatology and Venereology, Republican Screening Center, Research Center for Emergency Medical Care, Republican Specialized Research Center of Allergology, Republican Specialized Scientific-Practical Medical Center of Obstetrics and Gynecology, Republican Specialized Eye Microsurgery Center, Republican perinatal center of the Ministry of Health of the Republic of Uzbekistan.