In Simple Wording on the Principal Question
In questions of correct way of life and food - the basic factors of preservation of health and in the long run - longevity there are much more errors and myths, than in any other field of human knowledge. The Gafur Gulyam Publishers in Tashkent presented a book “In Simple Wording on the Principal Question”, in which an attempt was made to put an end to many controversial issues. Its author Pavel Chernysh is a guest of our newspaper.
There have always been a lot of controversies around different diets and their health benefits, many like to talk about how to lead a healthy lifestyle. Recently, this list of eternal topics has been replenished with new ones, the birth of which is connected with the achievements of science. Are genetically modified foods so dangerous, how scary are they? How to treat margarines, milk, fizzy drinks? On all these issues, absolutely opposite explanations were established in life. What to believe? You just need to know the whole truth about each issue. And this truth is available in the language of the new book of the Doctor of Medical Sciences Pavel Chernysh. The book contains only those recommendations that are confirmed by medical research. In an accessible form, the need to observe caution to various diets that appeared in popular literature lately is shown, the importance of an individual approach is shown when choosing physical exertion, the role of biologically active substances and vitamins in maintaining health. The information given on biochemistry and human physiology justify the recommendations on the organization of nutrition for both healthy and sick people. The book will be of interest to a wide range of readers interested in medicine, rational nutrition and just their health.
It is unique in that, according to its reading, everyone, knowing all the pros and cons of this or that question, will make independent conclusions for himself. There are no universal and categorical answers. Everything is good in moderation, and everyone defines it for himself. In this case, do not forget that health depends on your lifestyle, habits and nutrition.
Meanwhile, we could not miss the chance to ask the author a few questions about the results of his other research, which has already been well-known in the mass media. Pavel Chernysh graduated from the S.M.Kirov Military Medical Academy in the city of Leningrad. He was awarded the title Honored Health Worker of the Republic of Uzbekistan, and is the author of more than 75 scientific works on cardiology, endocrinology, five monographs on the right way of life and rational nutrition.
- Several years ago, the media reported that you are offering a new way of treating diabetes, which gives a chance for a full recovery. You abandoned the insulin theory and built their own development on the hypothesis of cortisol-dependence of diabetes mellitus. The publications said that pharmacies have the necessary pills for his treatment. But we do not hear anything about the results of this development. Tell us more about this.
- The problem of type II diabetes is very complex and multifaceted, so it is still impossible to solve it in the world. But, perhaps, the scientists are looking for an answer to this question “not quite there”. We suggested that the key link in the whole chain of metabolic disorders in diabetes mellitus type II may be an inadequate increase in the level of cortisol in the blood (or, as it is also called - the ‘stress hormone’) in a certain category of people for whom a relatively low level of birth is typical, but this is their individual norm.
Under stress, the level of cortisol in these individuals may increase by 2-3 times, although it does not leave the limits of the generally accepted norm, but be on its upper limit. This chronic increase in cortisol triggers a cascade of reactions, leading to the development of diabetes mellitus. In our study, we showed that the drug reduction in cortisol in patients with diabetes to certain levels causes them to lower blood glucose levels, and reduce the socalled insulin resistance, that is, there is an increase in the sensitivity of body tissues to their own insulin.
We believe that maintaining the level of cortisol in the blood for certain values within a year or a little more can lead to the disappearance of pathological circles that support the state of insulin resistance and cause the clinical manifestations of diabetes mellitus. Simply put, in a patient, diabetes can go away as a disease in about a year.
Unfortunately, until now, there are no drugs that safely reduce the level of cortisol in the blood. That drug, which we used in the experiment, is actually sold in pharmacies, is very cheap, but is used for other diseases. To recommend it for mass application to diabetics it is impossible, as it is poorly tolerated by them in those dosages that are necessary.
Most importantly, we have received confirmation that, acting on the level of cortisol, it is possible to positively influence the course of diabetes mellitus. If the research continues, it may radically change our understanding of this disease and help to cope with it.
- The media talked about the new way you developed a diagnosis of predisposition to diabetes, which helps to determine this feature long before its clinical manifestation. Please tell me where can I buy such a device so that I can examine the whole family?
- Such instruments as metabolic are not some exotic. They are available, fairly cheap and widely used for the selection of diets for athletes, for fitness classes, and also in clinical practice for calculating nutritional needs, for example in post-operative patients. It turned out that this device can also be used to diagnose a predisposition to diabetes mellitus type II.
A group of our scientists found that patients with diabetes respond to psychoemotional stress by a very definite change in metabolism in the body, which we called the “diabetic profile of metabolism”. Surprisingly, approximately 8% of healthy young people showed exactly the same changes in response to stress, as if they already experienced this disease.
With further examination, it was found that most of them had immediate relatives who had diabetes. This allowed us to conclude that the characteristics of the body’s reaction to unfavorable factors (stress) can serve as a marker of predisposition to this disease. The method of examination is fairly simple, takes 15-20 minutes and does not require any special training of a specialist. The introduction of it into a wide practice in the form of a screening survey would help to identify such persons and further orient them towards the choice of professions that are not associated with intensive stresses, excluding other risk factors for the development of diabetes.
- You are developing new methods of diagnosis and treatment of diabetes. Tell me, why reinvent the wheel when there is molecular-genetic diagnosis and PCR-analyzers?
- The fact is that until now there are no specific genes responsible for the development of type II diabetes mellitus. Most likely, they will not be found, although work is in progress in this direction. I repeat that diabetes mellitus is a multi-faceted disease, it is even thought that this is not one, but a group of similar diseases in its mechanism, so in this aspect there cannot be any specific genes. Given the known and diverse risk factors, this refers to the reaction of the organism to them as an integral system and the involvement of a very large number of genes in this reaction. In addition, genetic methods to date are laborious, require expensive equipment and are not available to most patients, not to mention healthy. And PCRanalyzers for these purposes are not intended at all.
- Since your previous book, “Why do we grow old?” have your beliefs about this process changed? In my opinion, a person can never understand this mystery, so why do scientists constantly want to please us that they managed to find a solution to the problem? Each time it turns out that the new assumptions are another mistake or have nothing plausible.
- The issue of aging is one of the fundamental mysteries of biology, which have been worrying mankind for thousands of years. That is why in this field of knowledge there are so many different kinds of speculation. As a rule, various kinds of publications in the media and appearances on television pursue one goal advertising.
Real scientists dealing with gerontology are never interested in excessive hype and will not publish untested or disputed data. Moreover, the modern achievements of gerontology can put before society the same real and acute issues in social, cultural, and economic spheres, therefore here, as in no other field of knowledge, a cautious and balanced approach is important.
- Tell me, can you slow down the aging process, and if ‘yes’, where can one read more about it?
- I am convinced that it is possible to influence it in terms of slowing down the issues of aging for more than 20 years. However, in life we often shorten our lives with harmful habits, wrong ways of life and ultimately do not live to the limit that is given to us by nature. Now before gerontologists, the task is not really an absolute extension of life as such, but how to prevent or, at any rate, slow the onset of senile infirmity and the development of age-related diseases, which become a heavy burden for both the person himself and his associates. Unfortunately, I cannot recommend any literature, because despite the abundance of various methods and techniques of prolonging life, and even more so of rejuvenation, a real extension of human life has not yet been achieved, including by the gerontologists themselves.
- What are you currently working on in the areas of diabetes and aging, and in others?
- With regard to diabetes and aging, the main points of my research we touched on above. At the same time, I also deal with tumor processes. At present, there is enough knowledge in this field that allows us to look at the processes underlying the degeneration of a normal cell into a cancerous cell, and give hope that the cancer will cease to be a fatal disease. And this will also contribute to the extension of life.