12 Taming the UV Master
If you prefer to control the UVS, you may want to try Enable Control Painting. With this, you can paint the areas red where you do not want the seams to appear, and blue to attract them. My preferred method involves polygroups. You can redo your polygroups to let Zbrush know where to place the seams. In the Zplugin>uv Master menu, click Work On Clone to avoid problems and activate Polygroups ( below Unwrap All button). Combining it with Control Painting results in much more controlled UVS.