Pro-Bi­otics: The Miss­ing Link Be­tween Equi­lib­rium & Growth

the miss­ing link to equi­lib­rium & growth

Australian Natural Bodz - - Contents - By Ge­orge L. Red­mon, Ph.D.

Ge­orge L Red­mon PHD takes us on a jour­ney into the world of Pro­bi­otics and how these tiny micro­organ­isms gov­ern many phys­i­o­log­i­cal mech­a­nisms that reg­u­late the body’s an­abolic, meta­bolic and bio-en­er­getic po­ten­tial.

Trends in sports nu­tri­tion have evolved to­ward uti­liz­ing mul­ti­pur­pose for­mu­las or prod­ucts. Adding pro­bi­otics to a protein pow­der would of­fer body­builders, ath­letes and health en­thu­si­ast im­mune pro­tec­tion plus a mul­ti­tude of ap­pli­ca­tions that en­hance pre- and post work­out ef­forts. Ad­di­tion­ally, new data in­di­cates that spe­cific strains of pro­bi­otics in­crease the uti­liza­tion of protein by the body, par­tic­u­lar­ity the amino acid leucine, as well as reg­u­late the an­abolic syn­ergy be­tween nu­tri­ents and the in­te­gral­ity of the an­abolic mi­lieu.

~ Gane­den Biotech Lab­o­ra­tory

In to­day’s body build­ing arena it is a uni­ver­sally ac­cepted prac­tice to uti­lize and or in­cor­po­rate sev­eral dif­fer­ent prod­ucts to ad­dress as­sorted meta­bolic and growth en­hanc­ing needs. This prac­tice is de­signed to gen­er­ate the syn­er­gis­tic en­ergy needed to il­licit an an­abolic re­sponse which other­wise wouldn’t oc­cur by us­ing a sin­gle prod­uct. How­ever, protein will al­ways be a core prod­uct as it is the ma­te­rial the body uses to string to­gether the var­i­ous com­bi­na­tions of amino acids that build mus­cle. While there ex­ist a va­ri­ety of prod­ucts like crea­tine and ni­tric ox­ide po­ten­tia­tors that also dom­i­nate the mar­ket­place, emerg­ing data in­di­cates that a non-tra­di­tional sports nu­tri­tional prod­uct has the pos­si­bil­ity to be­come syn­ony­mous with the phrase main­tains the equi­lib­rium of the body’s an­abolic mi­lieu.

Your In­ter­nal Mi­lieu: Your An­abolic Bat­tle ground

Mi­lieu is de­fined as the sur­round­ings or en­vi­ron­ment that some­thing lives in and is in­flu­enced by. From all in­di­ca­tions pro­bi­otics are that some­thing that im­proves the bio­chem­i­cal pro­cesses that gov­ern protein syn­the­sis which is the cre­ation of spe­cific cel­lu­lar pro­teins that ig­nite mus­cle de­vel­op­ment and growth. Emerg­ing data clearly shows that these pro­bi­otic micro­organ­isms gov­ern many other phys­i­o­log­i­cal mech­a­nisms that reg­u­late the body’s an­abolic, meta­bolic and bio­en­er­getic po­ten­tial. In ret­ro­spect, pro­bi­otics could be com­pared to a bat­tal­ion of highly trained navy seals dropped into a dan­ger­ous war zone to re­store and main­tain or­der within the an­abolic mi­lieu where these syn­er­gis­tic pro­cesses take place.

A Healthy Gut: Your Mi­lieu's Se­cret Weapon

Pro­bi­otics are de­fined by the World Health Or­ga­ni­za­tion as liv­ing micro­organ­isms (good bac­te­ria), which when ad­min­is­tered in ad­e­quate amounts, con­fer a health ben­e­fit to the host, mean­ing you. Pro­bi­otics gen­er­ate many good bac­te­ria like, bi­fidum, bi­fida bac­terium, lac­to­bacil­lus aci­dophilus, lac­to­bacil­lus bul­gar­ius and sac­cha­rmyces that train the im­mune sys­tem to work more ef­fi­ciently, while help­ing cells there to grow and de­velop. This equates to bet­ter sup­port against re­s­pi­ra­tory prob­lems in­di­vid­u­als en­gaged in in­tense work­outs some­times en­counter, as a re­sult of ex­er­cise in­duced stress which ac­cel­er­ates the de­struc­tion of good bac­te­ria. Pro­bi­otics help neu­tral­ize ox­i­da­tion by in­flam­ma­tory chem­i­cals that can ac­cu­mu­late in the gas­troin­testi­nal tract by pro­duc­ing or­ganic (liv­ing) com­pounds like lac­tic acid, hy­dro­gen per­ox­ide, and acetic acid that in­crease the acid­ity of the in­testines and in­hibits the re­pro­duc­tion of harm­ful bac­te­ria. Pro­bi­otic bac­te­ria also pro­duce sub­stances called aci­dophillin or bac­te­ri­ocins which act as nat­u­ral an­tibi­otics that kill un­de­sir­able micro­organ­isms.

A One 100 Tril­lion Dif­fer­ence

Re­searchers now know that over 80% of the im­mune sys­tem re­sides in the gut and serves as the cor­ner­stone of im­mune health, al­though the in­testi­nal tract com­prises mil­lions of stains of harm­ful bac­te­ria. In fact, gut bac­te­ria out num­ber the cells found in the body which equal about 10 tril­lion by a 10 to 1 ra­tio, mean­ing that some 100 tril­lion dif­fer­ent bac­te­ria live in the gut. Health of­fi­cials

state that about 85% of the gut bac­te­ria are ben­e­fi­cial and 15% can be harm­ful. How­ever, when these ra­tios re­main con­stant this union cre­ates an in­ter­nal en­vi­ron­ment re­searchers re­fer to as be­ing in a state of sym­bio­sis.

Talk­ing Bac­te­ria: Sym­bio­sis and Dys­bio­sis

Dr. Joseph Mer­a­cola, D.O., a Fel­low of The Amer­ica Col­lege of Nu­tri­tion states that bac­terium com­mu­ni­cate with one an­other us­ing a chemical lan­guage called quo­rum sens­ing. Dur­ing this ex­change in­di­vid­ual bac­te­ria se­crete small mol­e­cules that al­low them to count how many of its own kind there are while gaug­ing the strength of these ris­ing colonies. Once the colony reaches it crit­i­cal mass sen­sors di­rect bac­te­ria to act in a syn­chro­nized group to mul­ti­ply and neu­tral­ize the im­ped­ing dan­ger or wreck havoc. This is how good bac­te­ria con­trols the an­abolic mi­lieu and main­tains the an­abolic sym­me­try needed to oc­cur be­tween nu­tri­ents and var­i­ous or­gan sys­tems re­ferred to as sym­bio­sis. How­ever, when the ra­tio of good to bad bac­te­ria shifts to­ward over col­o­niza­tion of bad bac­te­ria this has a neg­a­tive im­pact on body chem­istry and dis­rupts nor­mal meta­bolic and an­abolic ac­tiv­ity re­ferred to as dys­bio­sis.

Pro­bi­otics Sym­bio­sis Im­pacts Nutrient Ab­sorp­tion and Growth

The pro­bi­otic sym­bi­otic state im­proves di­ges­tion of car­bo­hy­drates, fats and protein. With­out pro­bi­otic in­flu­ence proper di­ges­tion and ab­sorp­tion of key an­abolic nu­tri­ents would be se­verely ham­pered. Cur­rent data in­di­cates that this good bac­te­ria acts as a sec­ond di­ges­tive sys­tem in­creas­ing ab­sorp­tion of nu­tri­ents that are missed in the nor­mal di­ges­tive pro­cesses. Fur­ther­more, pro­bi­otics ac­tu­ally help the body make nu­tri­ents to counter pos­si­ble nutrient de­fi­cien­cies and are ab­so­lutely nec­es­sary for proper protein me­tab­o­lism and pro­duc­tion. This phe­nom­e­non has prompted re­searchers at the Na­tional Univer­sity of Ire­land to la­bel pro­bi­otics as the for­got­ten gut.

Pro­bi­otics De­fi­ciency Ac­cel­er­ated Catabolism

Sports medicine of­fi­cials con­tend that this is an im­por­tant aug­ment­ing and sure fire way to en­sure that all the food nu­tri­ents you con­sume are be­ing uti­lized prop­erly to nour­ish the phys­i­o­log­i­cal

pro­cesses that sus­tain the bio­chem­istry of growth and re­pair. Con­versely, Dr. Kenneth Block, M.D., of The In­sti­tute of Func­tional Medicine in Gig Har­bor WA., states that gain­ing lean mus­cle is more dif­fi­cult when the pro­bi­otics of the gas­troin­testi­nal tract are out of whack. This mishap forces the body into a state of catabolism, rob­bing skele­tal mus­cle tis­sue of valu­able nu­tri­ents to com­pen­sate for nu­tri­ents that haven’t been prop­erly me­tab­o­lized and or ab­sorbed. Some of the ba­sic ev­ery­day things that can dis­rupt nor­mal gut flora are: agri­cul­tural chem­i­cals, an­i­mal protein, anti-bac­te­rial soap, chlo­ri­nated wa­ter, con­sti­pa­tion, drugs (recre­ational and pre­scrip­tion; es­pe­cially an­tibi­otics, cor­ti­sone and oral con­tra­cep­tives), ex­cess su­gar, ex­er­cise, en­vi­ron­men­tal chem­i­cals, food ad­di­tives, pro­cessed foods, preser­va­tives and stress (phys­i­cal and emo­tion).

How Pro­bi­otics In­hibit Fat Ac­cu­mu­la­tion and Stor­age

One of the first stud­ies con­ducted in 2006 showed a clear link to obe­sity when com­par­ing gut flora be­tween obese and lean in­di­vid­u­als. Re­searchers found that this neg­a­tive shift in gut pro­bi­otics re­vealed 20% in­creases in bac­te­ria called fir­mi­cutes and nearly 90% less of bac­teroidetes. Fir­mi­cutes help the body ex­tract calo­ries from com­plex car­bo­hy­drates and de­posit them as fat, while bac­teroidetes worked in re­verse. Con­versely, sci­en­tist in Ire­land dis­cov­ered that the pro­bi­otic Lac­to­bacil­lus was re­spon­si­ble for the pro­duc­tion of the fatty acid t10/c12 CLA (con­ju­gated linoleic acid) which pre­vents stor­age of fat. Fur­ther­more, emerg­ing re­search in­di­cates that the pro­bi­otic Lac­to­bacil­lus Aci­dophilus in­creases the pro­duc­tion of the sati­ety hor­mone glucagon-like pep­tide (GLP-1) lep­tin to coun­ter­act the up reg­u­la­tion of neg­a­tive sig­nals trans­mit­ted by the hor­mone grehlin. Grehlin sends out er­ro­neous mes­sages that sig­nal the body to con­sume more calo­ries than needed and to store most of them as body fat. Ad­di­tion­ally, in a re­cent study ap­pear­ing in the Bri­tish Jour­nal of Nu­tri­tion in­ves­ti­ga­tors re­ported that pro­bi­otics dy­namic im­pact on fat cell lev­els and their re­duc­tion was a di­rect re­sult of a cause/ef­fect re­la­tion­ship in their abil­ity to min­i­mize and in some cases pre­vent the ab­sorp­tion of di­etary fat. Lastly, Ja­panese re­searchers in a ran­dom­ized con­trolled trial re­ported some as­ton­ish­ing re­sults con­ducted on sub­jected pre-dis­posed to­ward obe­sity. Par­tic­i­pants in this study for 12 weeks con­sumed fer­mented milk prod­ucts stan­dard­ized with 200g of the pro­bi­otic lac­to­bacil­lus gasseri. Re­search data showed sig­nif­i­cant changes in body weight, such as a :1.4% re­duc­tion in BMI(body mass in­dex), 1.4% re­duc­tion in weight, 4.6% re­duc­tion in vis­ceral ab­dom­i­nal fat, and a 3.3% re­duc­tion in sub­cu­ta­neous fat just be­low the skin.

Pro­bi­otics: A Fat Cells Worse Nightmare

For some time re­searchers where un­sure of the ex­act mech­a­nisms re­spon­si­ble for weight and fat re­duc­tion seen in gas­tric by­pass surgery pa­tients. How­ever, re­cent stud­ies con­ducted at The Depart­ment of Obe­sity, Me­tab­o­lism and Nu­tri­tion at the Mas­sachusetts Gen­eral Hospi­tal in Bos­ton have con­sis­tently shown that as much as 20% of the weight and fat loss achieved from gas­tric by­pass surgery is ac­tu­ally due to shifts in the bal­ance of bac­te­ria in gut.

Pro­bi­otics Reg­u­late The An­abolic / Growth Ax­iom

As you know protein is the raw ma­te­rial the body uses to string to­gether se­ries of amino acids known as pep­tides. Much like the al­pha­bet us­ing sin­gle letters to form words, sen­tences and para­graphs, these amino acids serve as build­ing blocks that form spe­cific pro­teins the body needs to ini­ti­ate growth and re­pair. How­ever, there are many fac­tors in­volved within the syn­the­sis of protein as well as its ab­sorp­tion and uti­liza­tion. As cited in the above cap­tion pro­bi­otics in sci­en­tific stud­ies have ex­hib­ited the abil­ity to en­hance the uti­liza­tion of protein, es­pe­cially the amino acid leucine. In fact, in a re­cent dou­ble blind cross­over study by re­searchers at the Gane­den Biotech Lab­o­ra­tory in May­field Ohio re­ported that in two weeks one bil­lion colony form­ing units (CFU’s) of the pro­bi­otic Gane­den BC30 ( bacil­lus co­ag­u­lans) with one serv­ing of protein in­creased the ab­sorp­tion rate of 23 dif­fer­ent amino acids. Of great im­por­tance here was the ef­fec­tive­ness of leucine in­creas­ing by 23%.

Pro­bi­otics: Up Reg­u­late Amino Acid Ef­fi­ciency

Leucine is uni­ver­sally ac­cepted as the prime sign­ing amino acid that ac­cel­er­ates protein syn­the­sis. From a phys­i­o­log­i­cal stand­point leucine stim­u­lates protein syn­the­sis re­sult­ing in ac­cel­er­ated cre­ation of new mus­cle tis­sue more ef­fi­ciently, by stim­u­lat­ing the bio-chemical path­way known as mTOR, (Mam­malian Tar­get of Ra­pamycin) . What is of great in­ter­est here is the fact that of all the amino acids, leucine is the only one

ca­pa­ble of stim­u­lat­ing protein syn­the­sis by it­self. Data also in­di­cated that the pro­bi­otic Ga­ne­gen BC30 in­creased the ef­fi­ciency of isoleucine by 20% and va­line by 7%. When these two amino’s unite with leucine they form the branch chain amino acids (BCAA’s), revered for their abil­ity to speed mus­cle re­cov­ery, as they are me­tab­o­lized right in the mus­cle by­pass­ing the di­ges­tive process. Fur­ther­more, via a process known as glu­co­neogen­sis BCAA’s are con­verted to glu­cose to fuel wan­ing mus­cle out­put and strength. Some additional in­creases in the ef­fec­tive­ness of amino acids via the above pro­bi­otic were cit­rulline (ni­tric ox­ide pro­duc­tion blood ves­sel di­la­tion) by 128%, glu­tamine (re­cov­ery and re­pair) 116%, or­nithine (growth hor­mone pro­duc­tion) 100% and tryp­to­phan (mood en­hance­ment and stress re­duc­tion) 100%.

Pro­bi­otics The Ph Fac­tor and An­abolic Sym­me­try

In a re­lated study Korean re­searchers re­ported that the pro­bi­otic L.reuteri im­proved protein syn­the­sis and re­duced al­ter­ations in 40 pro­teins that were con­sis­tently and sig­nif­i­cantly al­tered in low ph con­di­tions. The im­proved cat­e­gories in ref­er­ence to en­hanced protein syn­the­sis as cited by these sci­en­tist were: trans­port and bind­ing of pro­teins, tran­scrip­tion trans­la­tions, nu­cleo­tide me­tab­o­lism, amino acid syn­the­sis, car­bon en­ergy me­tab­o­lism and ph home­osta­sis. For­get the sci­en­tific jar­gon here, but com­pare the above phys­i­o­log­i­cal pro­cesses to scat­tered pro­teins try­ing to reach their des­ti­na­tion by fol­low­ing pre-de­ter­mine in­struc­tions: to form proper shape for good ab­sorp­tion, gen­er­ated by chemical mol­e­cules that pro­duce en­ergy in a large pool of cor­ro­sive acid. It is here were pro­bi­otics ex­ert a pow­er­ful re­sponse to re­store proper Ph. The po­ten­tial of hy­dro­gen (PH) of your in­ter­nal mi­lieu should be some­what al­ka­line to carry out an­abolic pro­cesses like protein syn­the­sis cor­rectly. An acidic en­vi­ron­ment on a scale of 1 to 10, 1 to 5 be­ing acidic dis­rupts meta­bolic ac­tiv­i­ties.

A Acidic En­vi­ron­ment Ac­cel­er­ates Catabolism Ever­where

This as­pect of pro­bi­otic sup­ple­men­ta­tion and its im­pact on you reach­ing and sus­tain­ing your full an­abolic po­ten­tial is crit­i­cal. For ex­am­ple, con­sider the fact that all reg­u­la­tory ac­tiv­i­ties by the body, breath­ing, circulation, di­ges­tion, hormonal pro­duc­tion, and so on and so on all seek to bal­ance Ph lev­els by dis­card­ing caus­tic me­tab­o­lized acid residues from body and mus­cle tis­sue with­out harm­ing liv­ing cells. Bot­tom line here, each time the body steps up to draw min­er­als and other nu­tri­ents to neu­tral­ize abra­sive acid, it is weak­ened. In ret­ro­spect, as cited in the above cap­tion, an­other one of those one mil­lion rea­sons to com­bine a pro­bi­otic with a protein pow­der. Sug­gested Dose: 8 to 10 bil­lion CFU’s (colony form­ing units) daily for 2 weeks fol­lowed by 1 to 3 bil­lion CFU’s

daily for main­te­nance, mean­ing re­pop­u­la­tion of good bac­te­ria.

Fit­ness Model Jake Sylvester

Fit­ness Model Si­mone Monique

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