Pro-Biotics: The Missing Link Between Equilibrium & Growth
the missing link to equilibrium & growth
George L Redmon PHD takes us on a journey into the world of Probiotics and how these tiny microorganisms govern many physiological mechanisms that regulate the body’s anabolic, metabolic and bio-energetic potential.
Trends in sports nutrition have evolved toward utilizing multipurpose formulas or products. Adding probiotics to a protein powder would offer bodybuilders, athletes and health enthusiast immune protection plus a multitude of applications that enhance pre- and post workout efforts. Additionally, new data indicates that specific strains of probiotics increase the utilization of protein by the body, particularity the amino acid leucine, as well as regulate the anabolic synergy between nutrients and the integrality of the anabolic milieu.
~ Ganeden Biotech Laboratory
In today’s body building arena it is a universally accepted practice to utilize and or incorporate several different products to address assorted metabolic and growth enhancing needs. This practice is designed to generate the synergistic energy needed to illicit an anabolic response which otherwise wouldn’t occur by using a single product. However, protein will always be a core product as it is the material the body uses to string together the various combinations of amino acids that build muscle. While there exist a variety of products like creatine and nitric oxide potentiators that also dominate the marketplace, emerging data indicates that a non-traditional sports nutritional product has the possibility to become synonymous with the phrase maintains the equilibrium of the body’s anabolic milieu.
Your Internal Milieu: Your Anabolic Battle ground
Milieu is defined as the surroundings or environment that something lives in and is influenced by. From all indications probiotics are that something that improves the biochemical processes that govern protein synthesis which is the creation of specific cellular proteins that ignite muscle development and growth. Emerging data clearly shows that these probiotic microorganisms govern many other physiological mechanisms that regulate the body’s anabolic, metabolic and bioenergetic potential. In retrospect, probiotics could be compared to a battalion of highly trained navy seals dropped into a dangerous war zone to restore and maintain order within the anabolic milieu where these synergistic processes take place.
A Healthy Gut: Your Milieu's Secret Weapon
Probiotics are defined by the World Health Organization as living microorganisms (good bacteria), which when administered in adequate amounts, confer a health benefit to the host, meaning you. Probiotics generate many good bacteria like, bifidum, bifida bacterium, lactobacillus acidophilus, lactobacillus bulgarius and saccharmyces that train the immune system to work more efficiently, while helping cells there to grow and develop. This equates to better support against respiratory problems individuals engaged in intense workouts sometimes encounter, as a result of exercise induced stress which accelerates the destruction of good bacteria. Probiotics help neutralize oxidation by inflammatory chemicals that can accumulate in the gastrointestinal tract by producing organic (living) compounds like lactic acid, hydrogen peroxide, and acetic acid that increase the acidity of the intestines and inhibits the reproduction of harmful bacteria. Probiotic bacteria also produce substances called acidophillin or bacteriocins which act as natural antibiotics that kill undesirable microorganisms.
A One 100 Trillion Difference
Researchers now know that over 80% of the immune system resides in the gut and serves as the cornerstone of immune health, although the intestinal tract comprises millions of stains of harmful bacteria. In fact, gut bacteria out number the cells found in the body which equal about 10 trillion by a 10 to 1 ratio, meaning that some 100 trillion different bacteria live in the gut. Health officials
state that about 85% of the gut bacteria are beneficial and 15% can be harmful. However, when these ratios remain constant this union creates an internal environment researchers refer to as being in a state of symbiosis.
Talking Bacteria: Symbiosis and Dysbiosis
Dr. Joseph Meracola, D.O., a Fellow of The America College of Nutrition states that bacterium communicate with one another using a chemical language called quorum sensing. During this exchange individual bacteria secrete small molecules that allow them to count how many of its own kind there are while gauging the strength of these rising colonies. Once the colony reaches it critical mass sensors direct bacteria to act in a synchronized group to multiply and neutralize the impeding danger or wreck havoc. This is how good bacteria controls the anabolic milieu and maintains the anabolic symmetry needed to occur between nutrients and various organ systems referred to as symbiosis. However, when the ratio of good to bad bacteria shifts toward over colonization of bad bacteria this has a negative impact on body chemistry and disrupts normal metabolic and anabolic activity referred to as dysbiosis.
Probiotics Symbiosis Impacts Nutrient Absorption and Growth
The probiotic symbiotic state improves digestion of carbohydrates, fats and protein. Without probiotic influence proper digestion and absorption of key anabolic nutrients would be severely hampered. Current data indicates that this good bacteria acts as a second digestive system increasing absorption of nutrients that are missed in the normal digestive processes. Furthermore, probiotics actually help the body make nutrients to counter possible nutrient deficiencies and are absolutely necessary for proper protein metabolism and production. This phenomenon has prompted researchers at the National University of Ireland to label probiotics as the forgotten gut.
Probiotics Deficiency Accelerated Catabolism
Sports medicine officials contend that this is an important augmenting and sure fire way to ensure that all the food nutrients you consume are being utilized properly to nourish the physiological
processes that sustain the biochemistry of growth and repair. Conversely, Dr. Kenneth Block, M.D., of The Institute of Functional Medicine in Gig Harbor WA., states that gaining lean muscle is more difficult when the probiotics of the gastrointestinal tract are out of whack. This mishap forces the body into a state of catabolism, robbing skeletal muscle tissue of valuable nutrients to compensate for nutrients that haven’t been properly metabolized and or absorbed. Some of the basic everyday things that can disrupt normal gut flora are: agricultural chemicals, animal protein, anti-bacterial soap, chlorinated water, constipation, drugs (recreational and prescription; especially antibiotics, cortisone and oral contraceptives), excess sugar, exercise, environmental chemicals, food additives, processed foods, preservatives and stress (physical and emotion).
How Probiotics Inhibit Fat Accumulation and Storage
One of the first studies conducted in 2006 showed a clear link to obesity when comparing gut flora between obese and lean individuals. Researchers found that this negative shift in gut probiotics revealed 20% increases in bacteria called firmicutes and nearly 90% less of bacteroidetes. Firmicutes help the body extract calories from complex carbohydrates and deposit them as fat, while bacteroidetes worked in reverse. Conversely, scientist in Ireland discovered that the probiotic Lactobacillus was responsible for the production of the fatty acid t10/c12 CLA (conjugated linoleic acid) which prevents storage of fat. Furthermore, emerging research indicates that the probiotic Lactobacillus Acidophilus increases the production of the satiety hormone glucagon-like peptide (GLP-1) leptin to counteract the up regulation of negative signals transmitted by the hormone grehlin. Grehlin sends out erroneous messages that signal the body to consume more calories than needed and to store most of them as body fat. Additionally, in a recent study appearing in the British Journal of Nutrition investigators reported that probiotics dynamic impact on fat cell levels and their reduction was a direct result of a cause/effect relationship in their ability to minimize and in some cases prevent the absorption of dietary fat. Lastly, Japanese researchers in a randomized controlled trial reported some astonishing results conducted on subjected pre-disposed toward obesity. Participants in this study for 12 weeks consumed fermented milk products standardized with 200g of the probiotic lactobacillus gasseri. Research data showed significant changes in body weight, such as a :1.4% reduction in BMI(body mass index), 1.4% reduction in weight, 4.6% reduction in visceral abdominal fat, and a 3.3% reduction in subcutaneous fat just below the skin.
Probiotics: A Fat Cells Worse Nightmare
For some time researchers where unsure of the exact mechanisms responsible for weight and fat reduction seen in gastric bypass surgery patients. However, recent studies conducted at The Department of Obesity, Metabolism and Nutrition at the Massachusetts General Hospital in Boston have consistently shown that as much as 20% of the weight and fat loss achieved from gastric bypass surgery is actually due to shifts in the balance of bacteria in gut.
Probiotics Regulate The Anabolic / Growth Axiom
As you know protein is the raw material the body uses to string together series of amino acids known as peptides. Much like the alphabet using single letters to form words, sentences and paragraphs, these amino acids serve as building blocks that form specific proteins the body needs to initiate growth and repair. However, there are many factors involved within the synthesis of protein as well as its absorption and utilization. As cited in the above caption probiotics in scientific studies have exhibited the ability to enhance the utilization of protein, especially the amino acid leucine. In fact, in a recent double blind crossover study by researchers at the Ganeden Biotech Laboratory in Mayfield Ohio reported that in two weeks one billion colony forming units (CFU’s) of the probiotic Ganeden BC30 ( bacillus coagulans) with one serving of protein increased the absorption rate of 23 different amino acids. Of great importance here was the effectiveness of leucine increasing by 23%.
Probiotics: Up Regulate Amino Acid Efficiency
Leucine is universally accepted as the prime signing amino acid that accelerates protein synthesis. From a physiological standpoint leucine stimulates protein synthesis resulting in accelerated creation of new muscle tissue more efficiently, by stimulating the bio-chemical pathway known as mTOR, (Mammalian Target of Rapamycin) . What is of great interest here is the fact that of all the amino acids, leucine is the only one
capable of stimulating protein synthesis by itself. Data also indicated that the probiotic Ganegen BC30 increased the efficiency of isoleucine by 20% and valine by 7%. When these two amino’s unite with leucine they form the branch chain amino acids (BCAA’s), revered for their ability to speed muscle recovery, as they are metabolized right in the muscle bypassing the digestive process. Furthermore, via a process known as gluconeogensis BCAA’s are converted to glucose to fuel waning muscle output and strength. Some additional increases in the effectiveness of amino acids via the above probiotic were citrulline (nitric oxide production blood vessel dilation) by 128%, glutamine (recovery and repair) 116%, ornithine (growth hormone production) 100% and tryptophan (mood enhancement and stress reduction) 100%.
Probiotics The Ph Factor and Anabolic Symmetry
In a related study Korean researchers reported that the probiotic L.reuteri improved protein synthesis and reduced alterations in 40 proteins that were consistently and significantly altered in low ph conditions. The improved categories in reference to enhanced protein synthesis as cited by these scientist were: transport and binding of proteins, transcription translations, nucleotide metabolism, amino acid synthesis, carbon energy metabolism and ph homeostasis. Forget the scientific jargon here, but compare the above physiological processes to scattered proteins trying to reach their destination by following pre-determine instructions: to form proper shape for good absorption, generated by chemical molecules that produce energy in a large pool of corrosive acid. It is here were probiotics exert a powerful response to restore proper Ph. The potential of hydrogen (PH) of your internal milieu should be somewhat alkaline to carry out anabolic processes like protein synthesis correctly. An acidic environment on a scale of 1 to 10, 1 to 5 being acidic disrupts metabolic activities.
A Acidic Environment Accelerates Catabolism Everwhere
This aspect of probiotic supplementation and its impact on you reaching and sustaining your full anabolic potential is critical. For example, consider the fact that all regulatory activities by the body, breathing, circulation, digestion, hormonal production, and so on and so on all seek to balance Ph levels by discarding caustic metabolized acid residues from body and muscle tissue without harming living cells. Bottom line here, each time the body steps up to draw minerals and other nutrients to neutralize abrasive acid, it is weakened. In retrospect, as cited in the above caption, another one of those one million reasons to combine a probiotic with a protein powder. Suggested Dose: 8 to 10 billion CFU’s (colony forming units) daily for 2 weeks followed by 1 to 3 billion CFU’s
daily for maintenance, meaning repopulation of good bacteria.
Fitness Model Jake Sylvester
Fitness Model Simone Monique