Sup­ple­ment Cen­tral

Australian Natural Bodz - - Contents -

Ag­ma­tine for fat loss and lean mus­cle growth. Ash­wa­gandha boosts nat­u­ral testos­terone lev­els. HMB free acid su­per-charges mus­cle re­cov­ery.

The sup­ple­ments in­dus­try is known for ex­ag­ger­at­ing the ef­fects of the pow­ders, pills and cap­sules it man­u­fac­tur­ers but just oc­ca­sion­ally a sup­ple­ment ap­pears of which the mak­ers un­der­es­ti­mate its worth. If you have read the 19-page ar­ti­cle by Itzhak Nis­sim in the Jour­nal of Biological Chem­istry, then you’ll know that ag­ma­tine is one of th­ese sup­ple­ments. Ag­ma­tine can do a lot more than help bodybuilders pump up their mus­cles. Ac­cord­ing to Nis­sim’s pub­li­ca­tion, ag­ma­tine is a per­fect slim­ming sup­ple­ment. And the an­swer to the ques­tion that was on the tip of your tongue is ‘no’. Nis­sim, who works at the Univer­sity of Penn­syl­va­nia, did not re­ceive money from a sup­ple­ments man­u­fac­turer, but from the Amer­i­can gov­ern­ment in the shape of the Na­tional In­sti­tutes of Health. Ag­ma­tine is a me­tab­o­lite of L-argi­nine. It stim­u­lates the en­zymes that ex­tract ni­tro­gen monox­ide from L-argi­nine – and it does this so ef­fec­tively that a dose as low as 1 g ag­ma­tine – on its own – daily al­ready has a con­sid­er­able ef­fect. Bodybuilders use ag­ma­tine mainly if they are look­ing to in­crease the blood sup­ply to their mus­cles dur­ing a work­out. In the pub­li­ca­tion that was re­cently pub­lished in the Jour­nal of Biological Chem­istry, Nis­sim gave lab rats 55-75 mg ag­ma­tine per kg body­weight daily to lab rats via their drink­ing wa­ter. The hu­man equiv­a­lent of this dose would be almost iden­ti­cal to the doses that body­build­ing sup­ple­ments man­u­fac­tur­ers ad­vise: about 1 g a day. Nis­sim gave some of his lab an­i­mals stan­dard food [SD], and oth­ers got food with ex­tra fat added [HFD]. In both groups ag­ma­tine [AGM] in­hib­ited weight gain. Ag­ma­tine boosted the ac­tiv­ity of the fat re­cep­tor PPARal­pha and the molec­u­lar switch PGC-1-al­pha in the liver cells. PGC-1-al­pha in­duces the mi­to­chon­dria to make more cells. And there are more sub­stances that do this too. What they all have in common is that they im­i­tate the ef­fect of caloric re­stric­tion. In his pub­li­ca­tion Nis­sim did not look at the to­tal amount of mus­cle mass, but he did ex­am­ine the com­po­si­tion of the mus­cle mass – and this changed in a way that makes one think that ag­ma­tine has a mus­cle-strength­en­ing ef­fect. The amount of pro­tein in the mus­cles in­creased and the amount of fat de­clined. The mus­cle-strength­en­ing ef­fect of ag­ma­tine is prob­a­bly a con­se­quence of the in­crease of cAMP ac­tiv­ity in the mus­cle cells, Nis­sim thinks. On pa­per ag­ma­tine looks like the per­fect slim­ming sup­ple­ment. More cAMP, more fat ox­i­da­tion, raised car­ni­tine syn­the­sis, more adiponectin, im­proved mi­to­chon­drial func­tion, more UCPs, higher calo­rie burn­ing – almost ev­ery­thing you could wish for. The only thing that might dis­ap­point strength ath­letes is the in­crease in glu­co­neo­ge­n­e­sis. Glu­co­neo­ge­n­e­sis im­pli­cates that cells con­vert valu­able amino acids into glu­cose. Cur­cumin in­hibits glu­co­neo­ge­n­e­sis. So might it be worth stack­ing cur­cum­i­nand ag­ma­tine? Source: Jpn J Phar­ma­col. 1968 Mar;18(1):30-8. Ef­fects of glu­curono­lac­tone and the other car­bo­hy­drates on the bio­chem­i­cal changes pro­duced in the liv­ing body of rats by hard ex­er­cise. Tamura S, Tsut­sumi S, Ito H, Nakai K, Ma­suda M.

Photo By Rob Bell Tan Choon Keat

One of Malaysia’s top Nat­u­ral Bodybuilders

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