CAN I RUN MY LESS– USED APPS FROM MY iCLOUD DRIVE?

Yes, it’s easy to store and run them there if you prefer. macOS manages this by making a local copy when needed. But if that app has been ‘evicted’ to iCloud, you’ll have to wait for it to download before it can run, which could take time. Also beware that apps storing data in iCloud could slow that more.