Pharmacy Daily

Vit D controvers­y

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VITAMIN D supplement­ation may be worthwhile in spite of a recent meta-analysis, according to Professor Rebecca Mason, professor of endocrine physiology at the University of Sydney.

The analysis had “lumped together” studies of high- and low-dose vitamin D, and those investigat­ing vitamin D in people with and without adequate calcium intake.

So although the systematic review and meta-analysis of 81 randomised controlled trials covering 53,000 participan­ts suggested that vitamin D supplement­s do not prevent fractures or falls, nor have any clinically meaningful effect on bone mineral density, the data sources are challengea­ble.

Mason also criticised the mix of studies in the review, which included trials of vitamin D alone, and trials with vitamin D plus calcium.

“This is a problem because several earlier meta-analyses also showed that where it works, it is vitamin D plus calcium, not vitamin D alone, that reduced fractures and falls,” she said.

Mason also identified other limitation­s - CLICK HERE.

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