Science Illustrated

CANCER

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Cancer cells only do what cells normally do: grow and divide. But cells that divide out of control are very hazardous. Apoptosis, or cell suicide is one of the most important processes regulating the quantity of cells, and preventing cancer. Cancer cells only develop when the apoptosis mechanisms do not function, or don’t take place in the way they are supposed to. A cell might avoid committing suicide because of a mutation or biochemica­l blockage in the signals that instruct it to undergo programmed cell death, so that the cell continues to divide, and might develop into a cancer tumour.

In cancer tumours, there are often mutations of the p53 gene, the one responsibl­e for halting cell division. Cervical cancer is due to a virus that disturbs the function of p53. This could result in uncontroll­ed growth of cells in the cervix and subsequent­ly the developmen­t of cancer tumours. When cancer cells develop, the cell itself or the immune system’s T cells try to activate apoptosis. But often, the cancer cell's apoptosis program has been damaged in several places of the signalling process, making it almost impossible to stop the unrestrain­ed cell growth.

 ??  ?? A cancer cell undergoes apoptosis. If no mass suicide occurs, the cell will go on dividing unrestrain­ed.
A cancer cell undergoes apoptosis. If no mass suicide occurs, the cell will go on dividing unrestrain­ed.

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