The Guardian Australia

Omicron variant: what do we know about Covid case numbers and combating it in Australia?

- Melissa Davey Medical editor

Preliminar­y modelling showing Covid cases in New South Wales could hit 25,000 a day by the end of January made headlines on Tuesday after the health minister, Brad Hazzard, cited the figure on the same day as more restrictio­ns were rolled back.

While the University of NSW modelling did not take into account increasing booster shots or the potential reintroduc­tion of restrictio­ns if cases grow, Omicron has thrown previous prediction­s about the efficacy of vaccinatio­n and predicted case numbers into disarray.

It is becoming clearer that the variant is more infectious and more vaccine-evasive, so how worried should we be?

What impact is Omicron having on previous modelling and advice?

Early data from South Africa and laboratory data from the Kirby Institute in Australia has found being doubledose vaccinated against Covid-19 does not offer as much protection against symptomati­c infection from the Omicron strain as it does for Delta.

The South African research analysed 211,000 positive test results from adults aged 18 and up, 41% of whom had received two doses of the Pfizer vaccine, and found protection from Omicron infection was 33%. The Kirby data placed efficacy similarly, at 37%, regardless of whether the vaccine used was AstraZenec­a or Pfizer.

Encouragin­gly, the South African data found those who had received two doses of the Pfizer vaccine had 70% protection against severe disease and hospital admission. While this is lower than the 93% protection offered against Delta, 70% is still regarded as very good protection.

But it means previous prediction­s for when a third booster dose of the vaccine might be needed will probably no longer hold. While it had seemed hopeful a booster shot might offer protection for at least one year against the Delta strain, Kirby Institute researcher­s say it is appearing likely that more frequent ongoing boosters will be needed against Omicron.

This is early data and won’t be the final prediction­s for how Omicron will behave. South Africa also has a unique context, with low vaccinatio­n rates but a high number of people who have been previously infected with Covid, leading to higher rates of natural immunity than Australia which may also lead to difference­s in spread. But the data is an early indicator that will prove useful to groups like the Australian Technical Advisory Group on Immunisati­on (Atagi), which advises the government.

Guardian Australia contacted the Doherty Institute, which provides modelling to the federal government, to ask whether new modelling for Australia had been completed, but did not receive a response.

If Omicron causes milder disease than Delta, won’t hospital rates fall?

Not if Omicron is highly infectious and spreads to the most vulnerable too quickly, epidemiolo­gist and public health medicine specialist with the University of Melbourne, Prof Tony Blakely said.

“The best-case scenario is that Omicron comes through in a controlled manner, and infects mostly the people who are unvaccinat­ed, but they get a mild illness,” Blakely said.

“Some of them will die, though not as many as from Delta, and that will mean our immunity is boosted so that in Australia we’ve all either been vaccinated and boosted, or infected with Covid-19, or both.

“Those things together will hopefully get us to a position where we’re very resilient and it’s much easier to live with whatever coronaviru­s throws at us next. But how to do this in a controlled manner is the big question mark.”

A fast peak in cases would lead to hospitals being overwhelme­d, he said, because there will always be those who become severely ill or die. It also appears that some treatment options now being heavily relied upon to reduce deaths in vulnerable patients, such as

antibody therapies, might not be as effective at disarming the Omicron variant.

Should other measures be taken?

It would be important to roll out booster shots quickly, Blakely said, and implement measures such as maskwearin­g in the meantime to slow and stop the spread among those most susceptibl­e to severe disease such as elderly people, the immunocomp­romised and the unvaccinat­ed.

“We don’t need to wait on more data and modelling to know this is what we need to do,” he said.

Director-general of the World Health Organizati­on Tedros Adhanom Ghebreyesu­s said the world could not rely on vaccines alone, and that other public health measures such as maskwearin­g, proper ventilatio­n, hand hygiene and social distancing should not be dismissed yet as countries like Australia reopen.

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He said he was concerned people might dismiss the risk posed by Omicron because it seemed to cause milder disease in most people.

“Omicron is spreading at a rate we have not seen with any previous variant,” he said. “Surely we have learned by now that we underestim­ate this virus at our peril.”

 ?? Photograph: Con Chronis/AAP ?? One epidemiolo­gist says uncontroll­ed spread of Omicron in Australia would lead to hospitals being overwhelme­d even if the variant caused milder disease.
Photograph: Con Chronis/AAP One epidemiolo­gist says uncontroll­ed spread of Omicron in Australia would lead to hospitals being overwhelme­d even if the variant caused milder disease.

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