Gulf Today

New revolution­ary drug to treat coronaviru­s

- Gulf Today, Staff Reporter

DUBAI: From the start of the pandemic, researcher­s, scientists, and antivirus specialist­s have worked around the clock to find a way to treat COVID-19. Codivir, an innovative new drug from Code Pharma, now appears to have the potential to revolution­ise the fight against the virus. In a successful phase 1 clinical trial, the affected patients were back on their feet within 48 hours without side effects.

Zyon Ayni, Founder and CEO of Code Pharma, said, “Codivir showed great success in clinical trials and already has received emergency approvals in different countries for the treatment of coronaviru­s patients. Our team at Code Pharma are now initiating a multi-country phase 2 study with a larger cohort and have submitted additional emergency approval requests to several affected countries. Our phase 1 study with Codivir in Brazil has proven the medication to be safe, and we were able also to demonstrat­e a reduction in the viral load of the patients during the course of the treatment.”

Codivir, a short synthetic 16 amino-acid peptide, derived from the HIV-1 integrase, was originally found in preclinica­l and clinical examinatio­ns to combat the HIV virus. Subsequent in-vitro studies conducted on behalf of Code Pharma at the British virology research laboratory Virology Research Services in London confirmed a potent antiviral activity against SARS-COV-2 and other RNA viruses such as influenza.

Code Pharma, which was specifical­ly set up to develop groundbrea­king medical solutions, then ran a Phase 1 clinical trial of Codivir in patients with COVID-19, approved in Brazil by the National Research Ethics Commission ( CONEP). The trial was conducted at Casa de Saúde, Vera Cruz Hospital in São Paulo, Brazil, with Dr Florentino Cardoso and results showed that Codivir has a high safety profile while significan­tly suppressin­g viral load with an antiviral effect noted as early as three days.

“Our phase 2 controlled study will be conducted in Spain, Brazil, South Africa, and Israel, with a larger cohort. In view of the submitted emergency approval requests and to meet the expected demand, the company is preparing for mass production of Codivir in different sites worldwide, starting in parallel with the phase 2 trial,” added Zyon.

Code Pharma experts currently working on the project include Dr. Eynat Finkelshte­in and Dr. Esmira Naftali and supporting the clinical trials are Dr Yotam Kolben from the Department of Medicine at Hadassah Medical Centre and Prof Shlomo L. Maayan, Director Infectious Disease division at the Barzilai Medical Centre in Ashkelon.

 ?? ?? Zyon Ayni, Founder and CEO of Code Pharma.
Zyon Ayni, Founder and CEO of Code Pharma.

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