‘Crazy idea’ gathers support
Some warn infecting volunteers with COVID-19 to boost herd immunity would violate moral principles of medicine
Dr. Eleftherios Diamandis admits it might look like a “crazy idea” to some.
In a paper posted on his cancer research lab’s website, the University of Toronto professor proposes setting up special hospitals where volunteers could be deliberately infected with low doses of the COVID-19 virus, helping build a protective herd immunity in the year or more before a vaccine becomes available. One colleague equated his suggestion to the Nazis’ medical experiments on concentration-camp prisoners.
But different versions of the provocative idea have slowly picked up support as the world looks for ways to escape economically devastating lockdowns, while keeping people safe from the novel coronavirus.
Quebec Premier Francois Legault cited the concept of herd immunity Thursday, saying science indicates it would be a mistake to keep the province in lockdown for months to come. “If everyone stays home, nobody will get immunized,” he said.
A U.S. group has recruited over 2,000 volunteers willing to be infected by COVID-19 as a way to more rapidly test potential vaccines.
Meanwhile, a few doctors and academics have gone further, suggesting health workers be voluntarily infected to create a potentially immune medical army. It would revive an ancient tactic — called variolation — where people were given a limited dose of smallpox to try to avoid a more devastating infection.
“It looks like a crazy idea — people say ‘No, no, no,’ ” admitted biochemist Diamandis, who heads the Advanced Centre for Detection of Cancer at Mt. Sinai Hospital. “(But) the isolation leaves billions of people without immunity, and at the end of the day we must achieve immunity one way or another. And this is one way.”
Naturally, though, the concept is controversial, with some scientists and bio-ethicists warning that it would violate basic moral principles of medicine and research — whether someone was given a vaccine first or not.
“I don’t subscribe to either of these proposals,” said Michael Houghton, a University of Alberta virologist developing a coronavirus vaccine under a federal government grant. “Infecting people to build herd immunity is wrong — you do that with a vaccine, not with the virus.”
Underlying the debate is the notion that the world will not be fully free of the COVID-19 threat until there is enough immunity to cut short transmission of the virus. That is often pegged at about 60 per cent of the population. The mostly likely way to achieve that state is with a vaccine. But despite numerous, hugely expedited development projects, experts say one won’t be ready for a year to 18 months.
Vaccine efficacy trials typically involve a group randomly picked to receive the new agent and one that receives a placebo, the immune response gauged as they go about their normal lives. Bioethicist Nir Eyal and colleagues at New Jersey’s Rutgers University proposed in a paper last month conducting trials where the subjects were purposely exposed to the virus to test the vaccine’s effectiveness, a measure they argued could shave months off the approval process.
To that end, the grass-roots group 1Daysooner said it had recruited almost 2,400 volunteers in 52 countries by Thursday afternoon to submit themselves to such studies.
Houghton agrees “challenge” trials would make the process faster, but argued they are only ethically acceptable when there’s an effective treatment for the disease in case the vaccine doesn’t work.