Sci­en­tists seek real way to mea­sure pa­tients’ pain

Toronto Star - - ENTERTAINMENT & LIFE - LAURAN NEERGAARD

WASH­ING­TON— Is the pain stab­bing or burn­ing? On a scale from one to 10, is it a six or an eight?

Over and over,17-year-old Sarah Tay­lor strug­gled to make doc­tors un­der­stand her some­times de­bil­i­tat­ing lev­els of pain, first from joint-dam­ag­ing child­hood arthri­tis and then from fi­bromyal­gia.

“It’s re­ally hard when peo­ple can’t see how much pain you’re in, be­cause they have to take your word on it and some­times, they don’t quite be­lieve you,” she said.

Now sci­en­tists are peek­ing into Sarah’s eyes to track how her pupils re­act when she’s hurt­ing and when she’s not — part of a quest to de­velop the first ob­jec­tive way to mea­sure pain.

“If we can’t mea­sure pain, we can’t fix it,” said Dr. Ju­lia Finkel, a pe­di­atric anes- the­si­ol­o­gist at Chil­dren’s Na­tional Med­i­cal Cen­ter in Wash­ing­ton, who in­vented the ex­per­i­men­tal eye-track­ing de­vice.

At just about ev­ery doc­tor’s visit you’ll get your tem­per­a­ture, heart rate and blood pres­sure mea­sured. But there’s no stetho­scope for pain. Pa­tients must con­vey how bad it is us­ing that 10-point scale or emoji-style charts that show faces turn­ing from smiles to frowns.

That’s prob­lem­atic for lots of rea­sons. Doc­tors and nurses have to guess at

ba­bies’ pain by their cries and squirms, for ex­am­ple. The aching that one per­son rates a seven might be a four to some­one who’s more used to se­ri­ous pain or ge­net­i­cally more tol­er­ant. Pa­tient-to-pa­tient vari­abil­ity makes it hard to test if po­ten­tial new painkillers re­ally work.

Nor do self-rat­ings de­ter­mine what kind of pain some­one has — one rea­son for trial-and-er­ror treat­ment. Are opi­oids nec­es­sary? Or is the pain, like Sarah’s, bet­ter suited to nerve-tar­get­ing medicines?

“It’s very frus­trat­ing to be in pain and you have to wait like six weeks, two months, to see if the drug’s work­ing,” said Sarah, who uses a com­bi­na­tion of med­i­ca­tions, acupunc­ture and lots of ex­er­cise to counter her pain.

The Na­tional In­sti­tutes of Health (NIH) is push­ing for de­vel­op­ment of what its di­rec­tor, Dr. Fran­cis Collins, has called a “pain-o-me­ter.” Spurred by the opi­oid cri­sis, the goal isn’t just to sig­nal how much pain some­one’s in. It’s also to de­ter­mine what kind it is and what drug might be the most ef­fec­tive.

“We’re not cre­at­ing a lie de­tec­tor for pain,” stressed David Thomas of NIH’s Na­tional In­sti­tute on Drug Abuse, who over­sees the re­search. “We do not want to lose the pa­tient voice.”

Around the coun­try, NIH­funded sci­en­tists have be­gun stud­ies of brain scans, pupil re­ac­tions and other pos­si­ble mark­ers of pain in hopes of fi­nally “see­ing” the ouch so they can bet­ter treat it. It’s earlystage re­search, and it’s not clear how soon any of the at­tempts might pan out.

“There won’t be a sin­gle sig­na­ture of pain,” Thomas pre­dicted. “My vi­sion is that some­day we’ll pull these dif­fer­ent met­rics to­gether for some­thing of a fin­ger­print of pain.”

NIH es­ti­mates 25 mil­lion peo­ple in the U.S. ex­pe­ri­ence daily pain. Most days Sarah Tay­lor is one of them. Now liv­ing in Po­tomac, Md., she was a tod­dler in her na­tive Aus­tralia when the swollen, aching joints of ju­ve­nile arthri­tis ap­peared. She’s had mi­graines and spinal in­flam­ma­tion. Then two years ago, the body-wide pain of fi­bromyal­gia struck; a flare-up last win­ter hos­pi­tal­ized her for two weeks.

One re­cent morn­ing, Sarah climbed onto an acupunc­ture ta­ble at Chil­dren’s Na­tional, rated that day’s pain a not-toobad three, and opened her eyes wide for the ex­per­i­men­tal pain test.

“There’ll be a flash of light for 10 sec­onds. All you have to do is try not to blink,” re­searcher Kevin Jack­son told Sarah as he lined up the pupil-track­ing de- vice, mounted on a smart­phone.

The eyes of­fer a win­dow to pain cen­tres in the brain, said Finkel, who di­rects pain re­search at Chil­dren’s Sheikh Zayed In­sti­tute for Pe­di­atric Sur­gi­cal In­no­va­tion. How? Some pain-sens­ing nerves trans­mit “ouch” sig­nals to the brain along path­ways that also al­ter mus­cles of the pupils as they re­act to dif­fer­ent stim­uli. Finkel’s de­vice tracks pupil­lary re­ac­tions to light or to non-painful stim­u­la­tion of cer­tain nerve fi­bres, aim­ing to link dif­fer­ent pat­terns to dif­fer­ent in­ten­si­ties and types of pain.

Con­sider the shoot­ing hip and leg pain of sci­at­ica: “Ev­ery­one knows some­one who’s been started on oxy­codone for their sci­atic nerve pain. And they’ll tell you that they feel it — it still hurts — and they just don’t care,” Finkel said.

What’s go­ing on? An opi­oid­like oxy­codone brings some re­lief by dulling the per­cep­tion of pain, but not its trans­mis­sion — while a dif­fer­ent kind of drug might block the pain by tar­get­ing the cul­prit nerve fi­bre, she said.

Cer­tain med­i­ca­tions also can be de­tected by other changes in a rest­ing pupil, she said. Last month, the Food and Drug Ad­min­is­tra­tion an­nounced it would help Al­gometRx, a biotech com­pany Finkel founded, speed de­vel­op­ment of the de­vice as a rapid drug screen.

Look­ing deeper than the eyes, sci­en­tists at Har­vard and Mas­sachusetts Gen­eral Hos­pi­tal found MRI scans re­vealed pat­terns of in­flam­ma­tion in the brain that iden­ti­fied ei­ther fi­bromyal­gia or chronic back pain.

Other re­searchers have found changes in brain ac­tiv­ity — where dif­fer­ent ar­eas “light up” on scans — that sig­nal cer­tain types of pain. Still oth­ers are us­ing elec­trodes on the scalp to mea­sure pain through brain waves.

Ul­ti­mately, NIH wants to un­cover bi­o­log­i­cal mark­ers that ex­plain why some peo­ple re­cover from acute pain while oth­ers de­velop hard-to-treat chronic pain.

“Your brain changes with pain,” Thomas ex­plained. “A zero-to-10 scale or a happy-face scale doesn’t cap­ture any­where near the to­tal­ity of the pain ex­pe­ri­ence.”

MANUEL BALCE CENETA THE AS­SO­CI­ATED PRESS

Wash­ing­ton-based Chil­dren's Na­tional Med­i­cal Cen­ter is test­ing an ex­per­i­men­tal de­vice that aims to mea­sure pain ac­cord­ing to how pupils re­act to cer­tain stim­uli.

MANUEL BALCE CENETA THE AS­SO­CI­ATED PRESS

“It’s re­ally hard when peo­ple can’t see how much pain you’re in,” says pa­tient Sarah Tay­lor, left.

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