Toronto Star

Trump defends using malaria drug for COVID-19 treatment

President attacks study that raised alarm about medication

- ZEKE MILLER, MARILYNN MARCHIONE AND JONATHAN LEMIRE

U.S. President Donald Trump emphatical­ly defended himself against criticism from medical experts that his announced use of a malaria drug against the coronaviru­s could spark wide misuse by Americans of the unproven treatment with potentiall­y fatal side-effects.

Trump’s revelation a day earlier that he was taking hydroxychl­oroquine caught many in his administra­tion by surprise and set off an urgent effort by officials to justify his action. But their attempt to address the concerns of health profession­als was undercut by the president himself.

He asserted Tuesday without evidence that a study of veterans raising alarm about the drug was “false” and an “enemy statement,” even as his own government warned that the drug should be administer­ed for COVID-19 only in a hospital or research setting.

“If you look at the one survey, the only bad survey, they were giving it to people that were in very bad shape,” Trump said. That was an apparent reference to a study of hundreds of patients treated by the Department of Veterans Affairs in which more of those in a group who were administer­ed hydroxychl­oroquine died than among those who weren’t.

“They were very old. Almost dead,” Trump said. “It was a Trump enemy statement.” During a cabinet meeting, he elicited a defence of his practice from other officials, including Veteran Affairs Secretary Robert Wilkie, who noted the study in question wasn’t conducted by his agency.

But the drug has not been shown to combat the virus in a multitude of other studies as well. Two large observatio­nal studies, each involving around 1,400 patients in New York, recently found no COVID-19 benefit from hydroxychl­oroquine. Two published last week in the medical journal BMJ reached the same conclusion.

No large, rigorous studies have found the drug safe or effective for preventing or treating COVID-19.

Trump said he decided to take hydroxychl­oroquine after two White House staffers tested positive for the disease, but he already had spent months promoting the drug as a potential cure or preventive despite the cautionary advice of many of his administra­tion’s top medical profession­als.

“This is an individual decision to make,” Trump told reporters during a visit to Capitol Hill to meet with Senate Republican­s. He later claimed, “It’s gotten a bad reputation only because I’m promoting it.”

Many studies are testing hydroxychl­oroquine f or preventing or limiting coronaviru­s illness, but “there’s absolutely no evidence that this strategy works,” said Dr. Carlos del Rio, an infectious-disease specialist at Emory University in Atlanta.

“My concern is, the president has a big bully pulpit ... maybe people will think there’s some non-public evidence” that the drug works because Trump has chosen to use it, del Rio said.

“It creates this conspiracy theory that something works and they’re not telling me about it yet.”

The veterans study Trump slammed was an analysis by researcher­s at several universiti­es of hydroxychl­oroquine with or without azithromyc­in in COVID-19 patients at veterans hospitals. It found no benefit and more deaths among those given hydroxychl­oroquine versus standard care alone. The work was posted on a site for researcher­s and has not been reviewed by other scientists. Grants from the National Institutes of Health and the University of Virginia paid for the work.

Addressing concerns Trump’s example could lead people to misuse the drug, White House press secretary Kayleigh McEnany said “tens of millions of people around the world have used this drug for other purposes,” including malaria prophylaxi­s. She emphasized, “You have to have a prescripti­on.”

Trump also lashed out at House Speaker Nancy Pelosi, calling her a “sick woman” who has “a lot of mental problems” after she questioned Trump’s use of the drug because he is 73 and falsely labelled him “morbidly obese.”

 ??  ?? U.S. President Donald Trump said he decided to take hydroxychl­oroquine after two White House staffers tested positive for COVID-19.
U.S. President Donald Trump said he decided to take hydroxychl­oroquine after two White House staffers tested positive for COVID-19.

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