基于双聚类的近10年罗汉果研究热点可视化分析

范建华1，梁敏 1，刘布鸣 1，2

1.广西中医药研究院，广西 南宁 530022；2.广西中药质量标准研究重点实验室，广西 南宁 530022摘要：目的 采用双聚类和可视化法分析近10年罗汉果研究，了解其研究热点及趋势。方法 计算机检

索中国知识资源总库（CNKI）2007 年 1 月－2016 年 12月罗汉果相关研究，检索时间为2017 年 2 月 20 日。采用 BICOMB、NetDraw、gCLUTO 及 SPSS19.0 软件对纳入文献进行双聚类和可视化分析，提取关键词并绘制社会关系网络图、可视化矩阵、山峰图和多维尺度分析图，分析高频关键词间的关联。结果 最终纳入文献

723 篇，其中 2012－2016 年该领域年发文量约为 70 篇；关键词共现网络图包括 76 个关键词，其中“罗汉果皂苷”“罗汉果甜苷”“提取工艺”“组培苗”“栽培技术”“品种”“生长发育”等处于核心地位；可视化矩阵和山峰图表明，该领域研究主题主要可分为6类；研究热点动态演化表明，“罗汉果花”“饮料”“总黄酮”“基因表达”“基因克隆”“酶”“凋亡”“罗汉果籽油”等将成为后续研究热点。结论 本研究揭示了近10年罗汉果研究逐渐成熟，正向深层次拓展。关键词：罗汉果；双聚类；可视化；BICOMB；gCLUTO；Ucinet；SPSS；数据挖掘

DOI：10.3969/j.issn.1005-5304.2017.11.022

中图分类号：R2-05；R282.71 文献标识码：A 文章编号：1005-5304(2017)11-0091-05

Visualization Study on Hot Spots of Research on Siraitiae Fructus in Recent Ten Years Based on Double Clustering Analysis

FAN Jian-hua1, LIANG Min1, LIU Bu-ming1,2 (1. Guangxi Institute of Traditional Medical and Pharmaceutical Science, Nanning 530022, China; 2. Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning 530022, China)

Abstract: Objective To use double clustering analysis and visualization method to analyze the research on Siraitiae Fructus in recent ten years; To know the hot spots and trend of research. Methods Relevant research about Siraitiae Fructus in CNKI from January of 2007 to December of 2016 was retrieved by computers, and the retrieval time was February 20th, 2017. BICOMB, NetDraw, gCLUTO and SPSS19.0 software were used to conduct double clustering analysis and visualization analysis for included articles. Keywords were analyzed, and social network graph, visualization matrix, peak image and multidimensional scaling analysis map were drawn. Correlation among high-frequency key words were analyzed. Results Totally 723 articles were included, among which 70 articles were issued during 2012–2016; 76 key words were obtained by key word co-occurrence network map, among which mogroside, MOG, extraction process, tissue culture, cultivation technology, varieties, growth and development were in the core position; visualization and the peak image showed that the topics in this research field could be divided into 6 categories; research hotspot dynamic evolution showed that Siraitiae Fructus flower, beverage, total flavonoids, gene expression, gene cloning, enzyme, apoptosis, and Siraitiae Fructus seed oil would be the hot spots of further study. Conclusion This study reveals that the research on Siraitiae Fructus in the recent ten years are becoming mature, and expand to deep level.

Key words: Siraitiae Fructus; double clustering analysis; visualization; BICOMB; gCLUTO; Ucinet; SPSS; data mining 罗汉果为葫芦科植物罗汉果 Siraitia grosvenorii （Swingle）C. Jeffrey ex A.M. Lu et Z.Y.Zhang 的干燥

果实，具有清热润肺、利咽开音、滑肠通便等功效[1]，为广西道地药材，主要分布于永福、临桂、兴安、全

州、资源、龙胜、融安、金秀等地[2]，1987 年，原卫生部将罗汉果列为药食同源品种，并将“中药现代化