Study on Medication Rules of HAO Wanshan for Treatment of Emotional Diseases

YU Hong, LU Yi, SUN Xiaofeng, XU Lili

YU Hong1, LU Yi2, SUN Xiaofeng3, XU Lili3

1. School of Chinese Culture Studies, Beijing University of Chinese Medicine, Beijing100029, China;

2. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;

3. Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China

Abstract: Objective To explore the medication rules of Professor HAO Wanshan for the treatments of emotional diseases; To provide references for clinical treatment of the diseases. Methods Prof. HAO’s medical records from November 2015 to March 2018 in outpatient of Chinese Medicine Clinic of Beijing University of Chinese Medicine were collected. Excel2010 was used to establish a database and descriptive statistics was conducted for frequency and dosage. Liquorice software layered network, weighted point mutual information and other data mining methods were used to analyze core medicinal combinations and compatibility rules. Cytoscape 3.6.0 was used for visual display.

Results Totally 316 medical cases and 340 times of visits were included. One visit of water pill prescription was excluded, so 339 prescriptions were included. High frequency Chinese materia medica were Citri Reticulatae Pericarpium (303 times), Bupleuri Radix (302 times), Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (297 times), Pinelliae Rhizoma Praeparatum (296 times) and Polygalae Radix (290 times). The core prescriptions were

Xiaochaohu Decoction, Guizhi Gancao Decoction, Wendan Decoction and Dingzhi Pills. The combinations were Pinelliae Rhizoma Praeparatum, Citri Reticulatae Pericarpium, Polygalae Radix, Glycyrrhizae Radix et Rhizoma Praeparata cum Melle, Bupleuri Radix, Codonopsis Radix, Poria, fried Ziziphi Spinosae Semen, fried Paeoniae Radix Alba, Acori Tatarinowii Rhizoma, Cinnamomi Ramulus, Scutellariae Radix, Poria cum Ligno Hospite, Albiziae

Cortes, Fructus Aurantii and Bambusae Caulis in Taenias. High frequency medicinal combinations of modified prescriptions were fried Gardeniae Fructus-Sojae Semen Praeparatum, Ophiopogonis Radix-Schisandrae Chinensis Fructus, Zingiberis Rhizoma Recens-Corydalis Rhizoma, Jiaosanxian, Morindae Officinalis Radix-Cirni Fructus, Anemarrhenae Rhizoma- Chuanxiong Rhizoma, Copyodos Rhizoma-Sepiae Endoconcha-Perillae Folium-Alpiniae Officinarum Rhizoma, Lycii Fructus-Ligustri Lucidi Fructus, Rehmanniae Radix Praeparata-Angelicae Sinensis Radix. The five strong compatibility medicinal combinations were Fossilia Ossis Mastrodi-Ostreae Concha, Hordei Fructus Germinatus-Crataegi Fructus, fried Ziziphi Spinosae-Albiziae Cortes, Poria cum Ligno Hospite-Fossilia Ossis Mastrodi and Poria cum Ligno Hospite-Ostreae Concha. Conclusion Prof. HAO’s treatment for emotional diseases focuses on the combination of diseases and syndromes. The core treatment should be dispersing stagnated liver qi for relieving qi stagnation, warming Shaoyang, reducing phlegm and calming emotion. Prescriptions should be modified on the basis of the core prescriptions to balance the heat and coldness in organs and qi, blood and yin and yang.

Keywords: HAO Wanshan; emotional diseases; experience of famous doctors; data mining; medication rules