Exploration on Medication Law of Xiao Chengcong in Treating Luteal Phase Defect Infertility Based on Data Mining

Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Abstract: Objective To analyze Professor Xiao Chengcong’s medication law in the treatment of luteal phase defect infertility using data mining technology; To discuss Professor Xiao Chengcong ’ s clinical experience. Methods The medical records of patients with luteal phase defect infertility who visited Professor Xiao Chengcong’s clinic from December, 2007 to December, 2021 were collected. The data were screened and entered into the FangNet Platform. Through frequency statistics, collaborative classification, drug-symptom association, drug clustering, property, taste and meridian, the medication law was analyzed. Results This study included 90 medical records, with 90 patients and 270 prescriptions. The most frequently used drugs for luteal phase defect infertility were Taxilii Herba, Dipsaci Radix, Morinda Officinalis Radix, Poria, and Ligustri Lucidi Fructus, etc.; the properties were mainly warm and mild; the mainly taste was sweet; the main meridians were kidney meridian and liver meridian. The drug cluster analysis showed that the main drug pairs were Taxilli Herba, Dipsaci Radix, Morindae Officinalis Radix. Conclusion Professor Xiao Chengcong believes that the pathogenesis of luteal phase defect infertility is deficiency of kidney-yang; therefore, the treatment should mainly focus on tonifying the kidney to support yang, with nourishing the liver, strengthening the spleen, and regulating the Chong and Ren meridians. Medication emphasis the drugs with mild property and medicinal pairs in clinic, showing the academic thought of “harmony and flexibility” of Xiao’s gynecology department in Yanjing.

Keywords: infertility; luteal phase defect; data mining; Xiao Chengcong; medication law