基于数据挖掘探讨喻闽凤治疗儿童抽动障碍用药规律

1.广州中医药大学第四临床医学院，广东 深圳 518000；2.深圳市中医院，广东 深圳 518033

摘要：目的 利用数据挖掘研究喻闽凤教授治疗儿童抽动障碍的用药规律。方法 收集2018年1月1日－2021年12月31日广州中医药大学第四临床医学院喻闽凤教授门诊治疗儿童抽动障碍病例，利用Excel2016建立数据库，利用古今医案云平台2.3.5进行用药频次、性味归经分析，关联规则分析、聚类分析及复杂网络分析。结果 共纳入首诊处方142首，涉及中药139味，高频药物为天麻、白芍、大枣、法半夏、炙甘草、玄参、太子参、茯苓、杜仲、牛膝，药性以温、平为主，药味多为甘、苦、辛味，主要归肝经、脾经，其后为肺经、胃经、肾经、心经等。关联分析得到37个常用药对，聚类分析得到3类药物组合，复杂网络分析得到的核心中药组成以牛膝木瓜汤和正阳汤为基础加减。结论 喻闽凤教授治疗儿童抽动障碍以脾虚肝旺为关键病机，从肝论治，以疏肝理气、清肝平肺、补肝息风为法，综合运用脏腑理论及五运六气理论指导儿童抽动障碍的治疗。

关键词：儿童抽动障碍；数据挖掘；喻闽凤；用药规律

中图分类号：R272.6 文献标识码：A 文章编号：2095-5707(2024)02-0074-05

DOI：10.3969/j.issn.2095-5707.202302122 开放科学（资源服务）标识码（OSID）：

Discussion on the Medication Law of Yu Minfeng in the Treatment of Tic Disorders in Children Based on Data Mining

DENG Linrong1, YU Minfeng1, FU Yao1, XU Dongya2

（1. The Fourth Clinical Medicine School of Guangzhou University of Chinese Medicine, Shenzhen 518000, China; 2. Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China）

Abstract: Objective To explore the medication law of Professor Yu Minfeng in the treatment of children with tic disorder with data mining. Methods The cases of children with tic disorder in the Fourth Clinical Medicine School of Guangzhou University of Chinese Medicine from 1 January 2018 to 31 December 2021 were collected. Excel 2016 was used to establish the patient database. The medicine frequency statistics, medicine properties, tastes and meridians, association analysis, clustering analysis and complex network analysis were performed by using the ancient and modern medical records cloud platform 2.3.5. Results A total of 142 first-diagnosed prescriptions were included, involving 139 kinds of Chinese materia medica. The high-frequency drugs were Atractylodis Macrocephalae Rhizoma, Paeoniae Radix alba, Jujubae Fructus, Pinelliae Rhizoma Praeparatum, Glycyrrhizae Radix et Rhizoma Praeparata cum Melle, Scrophulariae Radix, Pseudostellariae Radix, Poria, Eucommiae Cortex, and Cyathulae Radix. The properties were mainly warm and mild; the tastes were mainly sweet, bitter and pungent; the meridians were mainly liver and spleen meridians, which followed lung meridian, stomach meridian, kidney meridian基金项目：广东省名中医传承工作室建设项目（2020年）；广东省深圳市医疗卫生三名工程项目（SZSM201812064）；深圳市中医院“3030计划”中医临床研究项目（G3030202122）通讯作者：喻闽凤，E-mail：ymf69@163.com