The museum has three floors and the centre is a large atrium. There are various site-specific sculptures, video works and installations at the museum.
The museum is located along the Nervión river. The titanium-clad building is designed by Canadian American architect Frank Gehry, the museum is with 24,000 m2, of which 9.000 are dedicated to exhibition space, Gehry’s design creates a spectacular sculpture-like structure integrating within Bilbao’s urban pattern and its surrounding area. "the randomness of the curves are designed to catch the light". The interior "is designed around a large, light-filled atrium with views of Bilbao's estuary and the surrounding hills of the Basque country." The atrium, which Gehry nicknamed The Flower because of its shape, serves as the organizing centre of the museum. 42,875 titanium panels make up the iconic facade of the GMB. The titanium was mined in Russia it was processed. Arranged on three levels, the museum’s 20 exhibition galleries are interconnected by several bridges, corridors, elevators, and stairs.