Re­searchers De­velop DNA Se­quenc­ing-Based Method to De­tect Brain Tu­mour

Fiji Sun - - Aust/nz News - Xin­hua

AChi­nese-led re­search team has made a break­through in the de­tec­tion of brain tu­mours by us­ing se­quenc­ing of pa­tients’ tu­mor-de­prived DNA.

Brain­stem gliomas are tu­mors dif­fi­cult to cut out and have lim­ited treat­ment op­tions due to their lo­ca­tion in the brain. The dis­ease oc­curs fre­quently in chil­dren, and peo­ple with it sur­vive for less than one year.

De­spite nu­mer­ous clin­i­cal tri­als, chemo­ther­apy has proven in­ef­fec­tive. Tra­di­tional meth­ods to ob­tain tu­mor tis­sue in­clude surgery and biopsy for ex­am­i­na­tion, but they are risky, painful and costly.

Re­searchers from the Bei­jing Tiantan Hos­pi­tal, along with the Duke Univer­sity Med­i­cal Cen­tre of the United States, found that se­quenc­ing of cir­cu­lat­ing tu­mor DNA, or tu­mour-de­rived genes, from the brain fluid, could help gain tu­mour ge­netic in­for­ma­tion and track tu­mor pro­gres­sion.

“But the se­quenc­ing method is cheaper, faster and less in­va­sive,” said lead re­searcher Zhang Li­wei.

“It would bring rev­o­lu­tion­ary changes to the di­ag­no­sis and treat­ment of brain­stem gliomas in the fu­ture.”

Hel­mut Ber­ta­lanffy, di­rec­tor of the De­part­ment of Vas­cu­lar Neu­ro­surgery at the In­ter­na­tional Neu­ro­science In­sti­tute, said that the re­search was “an enor­mous help for pa­tients suf­fer­ing from such kinds of tu­mors,” and could “re­place the sur­gi­cal in­ter­ven­tion for biopsy.”

The re­search was re­cently pub­lished in the in­ter­na­tional jour­nal

Bei­jing:

A 3-year-old girl from East China’s Shan­dong prov­ince has be­come the youngest breast can­cer sur­vivor after un­der­go­ing treat­ment at a hos­pi­tal in Nan­jing, East China’s Jiangsu prov­ince.

In March, the mother of the girl Yanyan no­ticed some red and sticky stains on her sin­glet and in the fol­low­ing days, the stains fre­quently ap­peared on the girl’s clothes.

The mother be­came more scared when she found there was some­thing on the girl’s left chest, and the lump was soft and could move slightly. The mother took the girl to hos­pi­tal for ex­am­i­na­tions.

Doc­tors at some hos­pi­tals told the mother that the girl could be ma­tur­ing early and asked her not to add too much di­etary sup­ple­ments for the tod­dler. How­ever, the mother re­alised that she hardly added any sup­ple­ments for her daugh­ter, and she de­cided to take her to other hos­pi­tals, and fi­nally they went to Jiangsu Prov­ince Hos­pi­tal where doc­tors di­ag­nosed her the dis­ease.

Doc­tors de­tected the lump in Yanyan’s left breast and a swollen lymph node in her armpit. A biopsy con­firmed that the lump was a kind of breast can­cer that is com­monly as­so­ci­ated with adult women. Yanyan had se­cre­tory breast car­ci­noma, a rare and slow­grow­ing type of can­cer, ac­cord­ing to doc­tors, and she was the third and youngest pa­tient of the dis­ease in about half a cen­tury.

The doc­tors at the Jiangsu hos­pi­tal con­tacted the ex­perts at Har­vard Med­i­cal School and held video con­fer­ences to di­ag­nose and dis­cuss the treat­ment plans.

Con­sid­er­ing the surgery ef­fects on the girl as she grows up, the team fi­nally adopted a plan of re­mov­ing the lump while pre­serv­ing the mam­mary glands.

The breast can­cer spe­cial­ist Tang Jin­hai at the Jiangsu hos­pi­tal car­ried out the surgery. After re­mov­ing the bad tis­sues from the breast, doc­tors also took the lymph node for a biopsy. The biopsy showed neg­a­tive, which meant that the can­cer had not ex­tended to other places and doc­tors did not need to cut more tis­sues. Yanyan, who left the hos­pi­tal Mon­day, is set to have a full re­cov­ery now.

China Daily

Photo: China Daily

Yanyan, 3, re­ceives med­i­cal treat­ment at a hos­pi­tal in Nan­jing, East China’s Jiangsu prov­ince.

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