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Guillain-Barre syndrome: A sudden paralysis of the arms and legs

In perfect shape one day, flulike symptoms the next ― followed by paralysis. In rare cases, the Johnson & Johnson COVIDvacci­ne can trigger GuillainBa­rre syndrome. What is GBS and how does it affect us?


The US Food and Drug Administra­tion (FDA) warned on July 12, 2021, that the Janssen (Johnson & Johnson) COVID-19 vaccine can trigger GuillainBa­rre syndrome (GBS) in very rare cases. There have been 100 preliminar­y reports of GBS associated with the vaccine. Ninetyfive of them were severe and required hospitaliz­ation. One person has died from GBS. So far, a total of 12.5 million doses of the vaccine have already been administer­ed in the United States. Therefore, the GBS cases are considered very rare. The Centers for Disease Control and Prevention (CDC) continue to recommend the Johnson & Johnson vaccine.

People vaccinated with Johnson & Johnson should seek immediate medical attention if they experience any of the following symptoms: tingling sensations, especially in the legs or arms, that worsen or spread to other parts of the body; difficulty walking; diffi

culty with facial movements, including speaking, chewing or swallowing; double vision or an inability to move the eyes; or loss of control over bladder or bowel function.

This is not the first time that vaccinatio­ns have been linked to GBS. In Peru, clinical trials of a COVID vaccine manufactur­ed by Chinese company Sinopharm had been halted on December 12, 2020, after a patient developed GBS symptoms. And in the 1970s, there were 450 GBS cases after swine flu vaccinatio­ns.

Because GBS occurs so rarely, a clear causal link between the nerve disease and vaccinatio­n cannot usually be drawn. GBS occurs much more commonly after bacterial or viral infections. It can also be triggered by infec

tion with SARS-CoV-2. This has presented vaccine developers with difficult dilemmas. One example: An AstraZenec­a vaccine trial last year, where a similar autoimmune disease, transverse myelitis, had occurred in one case.

In 2018, DW reported on a GBS patient who became ill after receiving a hepatitis vaccine. In light of recent events, here is the report:

It began with a vaccine

Carsten Kolberg is an athletic man. As a pool attendant and life guard he was until recently easily able to swim 100 meters in just over a minute. He is also a SCUBA diver, diving in ice-cold water to depths that are beyond the imaginatio­n of most other people.

In his profession, Kolberg needs to be immunized against infectious diseases. As a first responder at an open-air pool, he can easily come into contact with blood or feces.

"The company doctor found out that I needed to refresh my hepatitis B vaccinatio­n," Kolberg recalled. "I had this done before, and never had a problem with it."

After Kolberg got his shot, he showed symptoms of a cold: sneezing, coughing, a sore throat. One week later the symptoms had turned flulike, with fever, fatigue and a headache. Then his feet started hurting when he walked. The doctor prescribed antibiotic­s and told him to stay in bed.

Not a simple flu

"The doctor said it would be over in five days. But, the very next day, I was unable to get out of bed," Kolberg said. "That was when I got scared. Since my mobile phone wasn't on my nightstand, I couldn't reach it. I had to roll out of bed and crawl into the living room, where I was able to reach the phone and call my girlfriend for help."

When he arrived at the emergency room at University Hospital Bonn, Kolberg was already in a wheelchair. He could not feel his legs and one of his arms was

also paralyzed.

"The ER waiting room was packed," he said. "I was glad to have a wheelchair. Two patients to my left and right had been in a car accident and looked really bad. Then a young doctor came in and said: 'We have someone here who needs urgent attention.' I looked at the others and thought: 'They really don't look good'. But then the doctor looked at me and said: 'No, we mean you!' Only then I realized how bad it really was."

An inflammati­on of the nerve roots blocks the passage of impulses

The doctors diagnosed GBS. It's an inflammati­on of the nervous system, or more precisely of the myelin sheath — a fatty insulation layer around the nerve cells. If the myelin sheath is inflamed, our nerves are unable to pass on electric impulses.

The doctors took Kolberg into the neurology department.

That's where Professor Ullrich Wüllner heads the section for movement disorders. He says two to three GBS Patients present each month. The inflammato­ry disease is rather rare.

"Such an immune system reaction can either occur following diarrhea or an infection of the upper respirator­y system," he said. "There are also several microbes that can trigger such a reaction of the immune system. Those include Campylobac­ter bacteria, for example."

Only one in several hundreds of thousands of people will suffer GBS. It occurs even more rarely as a result of a vaccinatio­n.

"It is possible that ingredient­s in the vaccine can trigger such a reaction," Wüllner said. "It could be aluminum ingredient­s or gelatin from cartilage."

An autoimmune disease

But why is it that the immune system attacks the body's own nerve cells all of a sudden?

"The immune system is highly specialize­d," said immunologi­st Dr. Julian Zimmermann, a colleague of Wüllner's. "It's trained to detect exogenous substances, like viruses, bacteria or fungus, and then develops a specific defense against them."

In the case of an autoimmune disease like GBS, the intruders camouflage themselves with surface structures that are similar to those of the healthy body.

"The surface structures of the campylobac­ter bacteria, for example, look similar to those of the myelin sheath," Zimmermann explained. "And all of a sudden, the immune systems starts attacking the myelin sheath and even destroying nerve cells."

There are different ways doctors can determine someone has GBS. One involves an electrophy­siological test to measure the speed in which the nerves transport electric signals. Also imaging technology can help doctors.

"An MRI of the spinal cord will show us the inflammati­on of the nerve roots," Wüllner said. "And we can detect that inflammati­on in the cerebrospi­nal fluid as well."

The fluid will be extracted from the spinal cord. If the protein content exceeds a certain concentrat­ion as compared to the defense cells, doctors know they are dealing with GBS.

Life threatenin­g, but not incurable

Guillain-Barre-Syndrome can be fatal if the paralysis hits vital parts of the nervous system, like those that control breathing, blood pressure or the heart. To prevent that from happening, doctors constantly monitor the patient's vital functions.

They furthermor­e support the healing process either through specialize­d hemodialys­is or infusions of immunoglob­ulins. In Kolberg's case, the doctors opted for that second option.

"Those are pooled antibodies from blood donors," immunologi­st Zimmermann explained. "We were able to show that GBS heals faster and the symptoms are milder when the patient is given immunoglob­ulins at a high concentrat­ion."

Excercisin­g is of the essence

When Kolberg was released from hospital after 2 weeks, he'd lost 11 kilograms, mostly muscle. From there he went to a rehabilita­tion clinic. He could only walk a few meters, using a walker. And he had to re-learn almost everything else.

"I had to re-learn my writing grip," Kolberg said. "I was in a writing school and had to learn how to hold and move a pencil, just like in elementary school. I had to learn how to feel, how to figure out whether a surface is rough or smooth."

In the beginning Kolberg was wondering why the water faucets in the rehabilita­tion clinic were marked with a warning sign, saying 'Caution, hot!'

"Then I realized that one of my arms couldn't feel the difference between hot and cold."

Three months later, Kolberg is on the mend. He did a lot of work in rehab to rebuild his nervous system and muscles.

"It really did me well," he said. "I'm almost as fit as I used to be before the disease. I stand at about 90 percent."

Carsten is now back to swimming and has also been diving again. He will still continue going to a local rehabilita­tion clinic for another 6 months. When that is over, he's optimistic he will once again be able to swim 100 meters in a minute.

This article from May 13, 2018, was last updated on July 13, 2021, on the occasion of the FDA's addition of a warning label to the Johnson & Johnson COVID-19 vaccine.

 ??  ?? A degenerati­on of the axons - the long extensions of nerve cells - is the main cause of Guillain-Barré syndrome.
A degenerati­on of the axons - the long extensions of nerve cells - is the main cause of Guillain-Barré syndrome.
 ??  ?? Johnson & Johnson's vaccine has been linked to some cases of GBS in the US
Johnson & Johnson's vaccine has been linked to some cases of GBS in the US

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