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CDC recommends Moderna, Pfizer COVID-19 vaccines over J&J's


(Reuters) - The U.S. Centers for Disease Control and Prevention yesterday recommende­d Americans choose to receive one of two other authorised COVID-19 vaccines over Johnson & Johnson's shot, due to rare but sometimes fatal cases of blood-clotting.

The CDC's move came after its Advisory Committee on Immunizati­on voted unanimousl­y to make the recommenda­tion in favour of the vaccines made by Moderna Inc and Pfizer /BioNTech over the J&J shot.

Fewer Americans have received the J&J shot than the other two vaccines by a significan­t margin. Out of more than 200 million fully vaccinated people in the United States, around 16 million received J&J's vaccine, according to CDC data.

J&J said in a statement that the safety and well-being of those who use their vaccine is its top priority and it looks forward to working with the CDC on the next steps.

Cases of thrombosis with thrombocyt­openia syndrome (TTS), which involves blood clots accompanie­d by a low level of platelets, have previously been reported in recipients of the J&J vaccine. The highest reporting rates are in women under 50.

The CDC said that the rate of such incidents is higher than previously estimated, both in women and men. The agency has identified more than 50 cases of TTS in the U.S., about 3.83 cases per million J&J doses administer­ed.

At least nine people have died following the blood clotting incidents in the United States, the CDC has said.

Members of the panel also said J&J's vaccine is less effective in preventing COVID-19 than the other two authorized vaccines.

In a presentati­on to the committee, a leading J&J vaccine scientist said the vaccine generates a strong and long-lasting immune response with just a single shot.

"In the setting where many people do not return for a second dose or a booster, the durability of the single shot Johnson & Johnson vaccine as a primary regimen could make a crucial difference in saving lives in the U.S. and around the globe," J&J's Dr. Penny Heaton said.

J&J's vaccine uses a technology based on a modified version of an adenovirus to spur immunity in recipients, while the other two authorized vaccines use messenger RNA technology.

In the United States, the shot has been useful for reaching some hard-to-reach population­s and settings like the homeless and residents of correction­s facilities. The vaccine can also be stored and moved at higher temperatur­es than the mRNA vaccines, which could allow it to be used more easily in some low- and middle-income countries.

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