Chem­istry No­bel for work on an­ti­body drugs, en­zymes

BioSpectrum (Asia) - - People News -

Frances Arnold of the Cal­i­for­nia In­sti­tute of Tech­nol­ogy, Ge­orge Smith from the Univer­sity of Mis­souri and Gre­gory Win­ter of Bri­tain’s MRC Lab­o­ra­tory of Molec­u­lar Bi­ol­ogy have been awarded 2018 No­bel Prize for Chem­istry for pi­o­neer­ing science in en­zymes and an­ti­bod­ies. Ac­cord­ing to the Royal Swedish Academy of Sci­ences, Arnold had trans­formed science by us­ing the prin­ci­ples of evo­lu­tion, ge­netic change and selec­tion, and to evolve new types of pro­teins very fast. Smith de­vel­oped a method us­ing a virus that in­fects bac­te­ria to pro­duce new pro­teins while Win­ter used the same phage dis­play tech­nique to en­gi­neer the evo­lu­tion of an­ti­bod­ies, with the aim of pro­duc­ing more ef­fec­tive medicines. The fruits of this work in­clude the world’s top-sell­ing pre­scrip­tion medicine, the an­ti­body in­jec­tion Hu­mira sold by Ab­bVie for treat­ing rheuma­toid arthri­tis and other au­toim­mune dis­eases. Hu­mira, or adal­i­mumab, was the first drug based on Win­ter’s work to win reg­u­la­tory ap­proval in 2002.

Ge­orge SmithGre­gory Win­ter

Frances Arnold

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