Chemistry Nobel for work on antibody drugs, enzymes
Frances Arnold of the California Institute of Technology, George Smith from the University of Missouri and Gregory Winter of Britain’s MRC Laboratory of Molecular Biology have been awarded 2018 Nobel Prize for Chemistry for pioneering science in enzymes and antibodies. According to the Royal Swedish Academy of Sciences, Arnold had transformed science by using the principles of evolution, genetic change and selection, and to evolve new types of proteins very fast. Smith developed a method using a virus that infects bacteria to produce new proteins while Winter used the same phage display technique to engineer the evolution of antibodies, with the aim of producing more effective medicines. The fruits of this work include the world’s top-selling prescription medicine, the antibody injection Humira sold by AbbVie for treating rheumatoid arthritis and other autoimmune diseases. Humira, or adalimumab, was the first drug based on Winter’s work to win regulatory approval in 2002.