IIT-R de­vel­ops nan­odots to fight cancer

BioSpectrum (India) - - SCIENCE NEWS -

A group of sci­en­tists at the In­dian In­sti­tute of Tech­nol­ogy Roor­kee has de­vel­oped flu­o­res­cent car­bon nan­odots that can serve as ther­a­nos­tic i.e. ther­a­peu­tic and di­ag­nos­tic, agents for cancer. These nano­sized car­bon ma­te­ri­als have been ex­tracted from the leaves of the rosy peri­win­kle plant.

Car­bon dots, also called car­bon quan­tum dots, are flu­o­res­cent ma­te­ri­als that are well-suited as both ther­a­peu­tic and di­ag­nos­tic agents for cancer be­cause of two unique char­ac­ter­is­tics – they are bio­com­pat­i­ble and can be rapidly ex­creted from the body and exhibit low tox­i­c­ity while producing a re­li­able op­ti­cal sig­nal. In ad­di­tion, they can be chem­i­cally mod­i­fied for use as mul­ti­modal probes and ther­a­peu­tic con­ju­gates.

The sci­en­tific team is plan­ning next stage an­i­mal stud­ies for fur­ther eval­u­a­tion of these nano­ma­te­ri­als in on­co­log­i­cal ap­pli­ca­tions, for both di­ag­nos­tics and treat­ment. They will con­cur­rently study the fac­tors that would af­fect the per­for­mance and use of car­bon nan­odots in cancer ther­a­n­otics, in­clud­ing de­vel­op­ing ef­fi­cient means of de­liv­ery, pro­cesses for con­ser­va­tion of nan­odot bioac­tiv­ity and the en­hance­ment of speci­ficity to­wards the tar­get cells.

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