IISc sci­en­tists link OCD with au­toim­mune dis­or­der

BioSpectrum (India) - - SCIENCE NEWS -

Sci­en­tists at the Ben­galu­rubased In­dian In­sti­tute of

Sci­ence (IISc) have found that a class of cells that de­fends the body against in­vaders also trig­gers ob­ses­sive-com­pul­sive be­hav­iour in pa­tients suf­fer­ing from au­toim­mune dis­or­ders such as Mul­ti­ple Scle­ro­sis.

The team has found this out while study­ing a mice model ex­hibit­ing Mul­ti­ple Sclero­sis­like con­di­tions. They found that im­mune cells called Th17 lym­pho­cytes in­duced be­hav­iour sim­i­lar to OCD such as ex­ces­sive groom­ing. The ob­ses­sive groom­ing, how­ever, re­duced when the mice were given an anti-de­pres­sant that boosts the up­take of sero­tonin, an im­por­tant chem­i­cal mes­sen­ger. This sug­gested that the Th17 cells even­tu­ally dis­rupted sero­tonin up­take giv­ing rise to the Ob­ses­sive Com­pul­sive Dis­or­der (OCD) symp­toms.

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