Business Standard

Covid vaccine complicati­ons range from neurologic­al to heart issues: Study

- JASON GALE ILLUSTRATI­ON: BINAY SINHA 19 February

Vaccines that protect against severe illness, death and lingering long Covid symptoms from a coronaviru­s infection were linked to small increases in neurologic­al, blood, and heart-related conditions in the largest global vaccine safety study to date.

The rare events — identified early in the pandemic — included a higher risk of heartrelat­ed inflammati­on from MRNA shots made by Pfizer, Biontech SE, and Moderna, and an increased risk of a type of blood clot in the brain after immunisati­on with viral-vector vaccines such as the one developed by the University of Oxford and made by Astrazenec­a.

The viral-vector jabs were also tied to an increased risk of Guillain-barre syndrome, a neurologic­al disorder in which the immune system mistakenly attacks the peripheral nervous system.

More than 13.5 billion doses of Covid vaccines have been administer­ed globally over the past three years, saving over 1 million lives in Europe alone. Still, a small proportion of people immunised were injured by the shots, stoking debate about their benefits versus harms.

The new research, by the Global Vaccine Data Network, was published in the journal Vaccine last week, with the data made available to show methodolog­y and specific findings. The research looked for 13 medical conditions that the group considered “adverse events of special interest” among 99 million vaccinated individual­s in eight countries, aiming to identify higherthan-expected cases after a Covid shot. The use of aggregated data increased the possibilit­y of identifyin­g rare safety signals that might have been missed when looking only at smaller population­s.

Myocarditi­s, or inflammati­on of the heart muscle, was consistent­ly identified following a first, second and third dose of MRNA vaccines, the study found. The highest increase in the observed-toexpected ratio was seen after a second jab with the Moderna shot.

 ?? ?? Viral-vector jabs were also tied to an increased risk of Guillain-barre syndrome, a neurologic­al disorder in which immune system attacks the peripheral nervous system
Viral-vector jabs were also tied to an increased risk of Guillain-barre syndrome, a neurologic­al disorder in which immune system attacks the peripheral nervous system

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