Succinate production method that is renewable and efficient
Succinate is an extremely useful raw ingredient for petrochemicals, and there is high demand for a way of producing succinate that is renewable and environmentally benign.
A Japanese researcher has discovered that succinate production levels increase when cyanobacteria are grown above the ideal temperature for cell growth. He used insights into the metabolic pathway engineering to achieve the world’s most efficient production rate for bio-succinate, as per the report by Kobe University, Japan.
The discovery was made by Professor Tomohisa Hasunuma ( Kobe University Graduate School of Science, Technology and Innovation) as a Japan Science and Technology Agency Strategic Basic Research Program.
Professor Hasunuma’s research team aimed to find the reaction that acts as the bottleneck in the metabolic pathway when CO is converted into succinate, and
2 then use genetic engineering to speed up this bottleneck reaction and increase the production of succinate.
The team has managed to raise the production rate of succinate to 7.5 times higher than previous studies.