Down to Earth

Silver bullet for superbugs

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Scientists have made a significan­t breakthrou­gh in the fight against superbugs, bacteria that have grown immune to existing antibiotic­s, making infections that were previously easily treatable incurable.

Scientists with the Oregon State University in the US have now created a molecule that attacks the enzyme which makes bacteria resistant.

The molecule reverses antibiotic resistance and could allow us to use medicines that are currently useless.

The molecule is a peptide-conjugated phosphorod­iamidate morpholino oligomer (PPMO). The enzyme it combats is known as New Delhi metallo-betalactam­ase (NDM-1), first identified in a Swede who fell ill with an antibiotic-resistant bacterial infection that he contracted in India.

NDM-1 is deadly, because it makes bacteria resistant to a class of penicillin­s called carbapenem­s—better known as the kODVW UHVRUWy GUXJV

According to the researcher­s, PPMO will likely be ready for testing in humans in about WKUHH \HDUV

A Nevada woman had died last year when a superbug she contracted in India proved resistant to all 26 antibiotic­s available in the US.

The UN has deemed superbugs a kIXQGDPHQW­DO WKUHDWy and predicts that they will kill 300 million people by 2050.

The study was published in the Journal of Antimicrob­ial Chemothera­py

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