PGI DOCTORS DEVISE NEW TECHNIQUE TO LOWER CHOLESTEROL
Doctors at the Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGI) have invented a new technique to lower cholesterol in humans.
Assistant professor Dr Rohit A Sinha and PhD scholar Sangam Rajak, of the department of endocrinology, in collaboration with researchers from Italy and Singapore, found that a gene known as ULK1 was shown to regulate liver cholesterol production.
They showed that drugbased inhibition of ULK1 significantly reduces the biosynthesis of cholesterol producing enzymes, leading to the lowering of cholesterol levels in human hepatic cells and mouse models.
The identification of ULK1 gene as regulator of human cholesterol synthesis was made possible by an unbiased next generation sequencing methodology, which discovered that liver cells lacking ULK1 protein had deficient cholesterol synthesis.
Dr Sinha said, “Cholesterol is known to play a major role in human health. Hypercholesterolemia or increase in blood cholesterol is a major risk factor for development of several diseases such as atherosclerosis, hypertension, stroke and even more recent Covid-19 pathogenesis. Cardiovascular diseases are the major killers in most developed countries, including India, where they result in around 30 per cent of all adult deaths. We can control cholesterol related deaths with the help of this discovery.”
HT Correspondents
Chief minister Yogi Adityanath on Thursday assailed the opposition parties for the ‘goondaism’ that prevailed during their rule and said Prime Minister Narendra Modi had accomplished the task of bringing about a pivotal change in politics in the country.
Addressing rallies in Firozabad and Bulandshahr in support of party candidates contesting the state assembly by-polls, the chief minister also cited his government’s achievements.
In Tundla (Firozabad), addressing a rally in support of party candidate Prem Pal Singh Dhangar, Yogi congratulated the residents on expressing faith in the BJP to end ‘goondaism’ once and for all. He claimed that there had been no riot in the state in the past three years and those inciting violence were now behind bars. To note, Tundla and six other assembly seats go to by-poll on November 3.
Assuring a food processing unit in the area, the chief minister lauded farmers for keeping the economic situation moving during corona times. “Firozabad residents ended goondaism by
Chief minister Yogi Adityanath addressing a rally in Tundla.
voting for the BJP but the Samajwadi Party has not mended its ways and has fielded the father of a gang rape accused in the by-election,” the chief minister said. ‘There has been no riot in UP for the past three years. About 3 lakh youth have been provided jobs and farmers are getting fair price. But this is not acceptable to the opposition,” he said.
He also cited beginning of Ram Temple construction in Ayodhya and ending of Article 370 in Kashmir. Article 370 was causing terrorism yet opposition parties were against it as they found vote banks in terrorism also, said Yogi. In Bulandshahr, the CM addressed a public meeting in support of party candidate Usha Sirohi for the by-election on Bulandshahr Sadar assembly seat, which fell vacant after the death of BJP MLA Virendra Singh Sirohi.
The CM said that he had started the campaign in Bulandshahr in 2017 and the strength given by the people was being
utilised aptly. Listing the achievements of his government, he said that in western UP, the rioters were in prison while bulldozers had been run on illegally amassed properties of land mafia . “Goons are now begging for their lives,” he claimed.
Taking on the opposition parties, (Congress, -SP and BSP), the CM asked how would parties which were not able to rise above nepotism do good to people ? Targeting the Congress, he said that it wanted to divide people on the lines of caste and religion. Attacking Rashtriya Lok Dal without mentioning the name , Yogi asked if those believing in Chaudhary Charan Singh worked for the welfare of farmers. The BJP had fulfilled the dreams of Ch Charan Singh , he said.
The CM said that in police recruitment, many youths of western UP got jobs while from a village of Baghpat 29 youths got selected. Also mentioning Jewar airport he said that Bulandshahr district would get its maximum