Hindustan Times ST (Jaipur)

Gene editing can make us different, but not better

The genetic change, even if it worked as advertised, would not be a clear-cut improvemen­t but a trade-off

- The views expressed are personal Bloomberg Opinion

tion to make people in some way better able to serve corporatio­ns or the state.

There are some legitimate­ly bad genes, and scientists are working on so-called gene therapy to help people who’ve inherited them. But there are already safe ways for genetic diseases to be avoided, rather than edited. If people want to have children biological­ly and know they carry a mutation that puts their offspring at risk for a serious genetic disease, they can opt for something called pre-implantati­on diagnosis. This is genetic testing of embryos produced to ensure only ones without the deleteriou­s mutation are implanted.

There are rare cases where genes can be both common and seemingly undesirabl­e. One of these is a gene called ApoE4. Scientists studying a South American hunter-gatherer group called the Tsimane found that people with ApoE4 had a lower risk of Alzheimer’s – the opposite of the effect on typical subjects – but only if they also had certain parasites. Because most Tsimane people had parasites, ApoE4 was beneficial. This opens up the possibilit­y that in the future, scientists will have figured out how to simulate the effect of parasites, and people with one or two copies of ApoE4 will be at less risk than the rest of us.

Life on earth has been evolving for 3.8 billion years and yet our planet has yet to produce a perfect species. That won’t stop people from trying. It seems inevitable that someone will eventually try to sell people genetic tweaks to give their kids a higher IQ. Who knows? Such a thing might make some of us quicker, but probably not wiser. I recently read an article on a celebrity wedding, full of self- opinionate­d disrespect. It initiated my contemplat­ion on the cynics of the world. Cynics often come across as derisive, insolent, and condescend­ing. Consequent­ly, they miss out on spontaneou­s relationsh­ips and friendship­s. Cynicism can be manifested with pessimism, leading to social disengagem­ent and negative contributi­ons to the public domain. The line between cynicism and accurate observatio­n

 ?? AP ?? Chinese scientist He Jiankui says he helped make the world’s first geneticall­y edited babies: twin girls whose DNA he altered. Qin Jinzhou (in photo) is an embryologi­st in He’s lab
AP Chinese scientist He Jiankui says he helped make the world’s first geneticall­y edited babies: twin girls whose DNA he altered. Qin Jinzhou (in photo) is an embryologi­st in He’s lab

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