‘Testing vaccine candidate for new, future mutations’
Biological E’s vaccine candidate works well to control Sars-cov-2 variants of concerns, and work has already begun to make alterations in case more resistant mutations occur, according to Dr Maria Elena Bottazzi, one of the leading scientists who is part of the development team. In an interview with HT’S
Bottazzi, the associate dean of Baylor College of Medicine’s National School of Tropical Medicine, said Biological E’s recombinant DNA vaccine could address a large gap in global supplies in general, and help inoculate children in particular, and spoke of the need to ensure second doses are given on time to reduce the risk of mutations. The Baylor College of Medicine has partnered with Biological E for vaccine.
a global clinical trial.
I think they’re finishing up compiling all the data from the Phase 1/2 stages and the company will probably provide more information soon. They have already received the approval for Phase 3 trials, so you will probably see that they’re going to be launching that in the next week. ing the vaccine candidate and have already transitioned to Biological E additional constructs for them to evaluate. But the vaccine that they are currently advancing is quite cross-protective and performs well against variants of concern. At the same time, we’re looking for alternatives in case in the future, we need to redesign the vaccine. We have constructs for Sars, and for Mers, and now we have a toolbox of different constructs against Covid-19, so we’re looking at ways to develop second- and third-generation vaccines.
The yeast expression technology (the platform used) is the mainstay for a lot of vaccines -- it’s the same process used for the Hepatitis B vaccine, which is widely used in paediatric population. There is a lot of experience in quality production, and regulators are quite abreast of the safety. After authorisation (for adults), Biological E will start looking at evaluation in paediatric populations. you maximise the immune response, but at the same time, you don’t have enough vaccines to cover as many people as possible.
I appreciate the stress of wanting to make sure a lot of people start getting vaccinated, but if you start vaccinating people that are not fully protected, that may also open the window for this virus to continue mutating and enabling it to escape immunity.
Scientifically, we favour that individuals stay within the vaccine schedule.
If we continue to have this very patchy world, where there are areas where you’re doing a really good job in access and distribution of vaccines but in other areas you don’t, I think there’s going to be more of this emergence of variants of concern.
It is most likely going to require all of us get a booster shot sometime late this year or early next year. And this is, again, another reason why we now first need to ensure we have enough vaccines to catch up areas where there is still a lag in coverage.
At the same time, we will also need to have availability to fill gaps for other ages, including the paediatric population. So, the real urgency is of continuing to ramp up production, ensuring there’s enough reagents, and have a good ecosystem for distributed storage.