Neona­tal di­a­betes rear­ing its ugly head in In­dia

Hindustan Times ST (Mumbai) - HT Navi Mumbai Live - - FRONT PAGE - Priyanka Vora

MUMBAI: Six-month-old Ishaan ( name changed) is ad­min­is­tered two in­sulin shots ev­ery day, to keep his blood sugar lev­els in check. His Mumbai-based par­ents, who are not di­a­bet­ics, won­der how their child got the dis­ease. Ishaan’s doc­tors ini­tially sus­pected he had type-I di­a­betes, a con­di­tion com­mon in chil­dren and young adults, but re­cently they dis­cov­ered that a mu­ta­tion in his gene has re­sulted in him suf­fer­ing from a con­di­tion called neona­tal di­a­betes mel­li­tus (NDM).

The re­ported in­ci­dence of NDM across the world varies from 1 in 89,000 to 1 in 4 lakh live births and could be higher in com­mu­ni­ties where con­san­guineous (blood-re­lated) mar­riages hap­pen. There are 26 l akh l ive births in In­dia, but only 181 chil­dren are reg­is­tered at Neona­tal Data Reg­istry, which is sup- ported by the In­dian Coun­cil of Med­i­cal Re­search (ICMR).

“T here i s no s t udy on NDM preva­lence in In­dia, but hos­pi­tal- based stud­ies show it to be 1 in 125 type- 1 di­a­betes pa­tients,” said Dr V Mo­han, chair­man and chief di­a­bol­o­gist at Dr Mo­han’s Di­a­betes Spe­cial­i­ties Cen­tre (MDRF), Chen­nai, which runs In­dia’s only Neona­tal Data Reg­istry. “There are no re­ports on re­gion- spe­cific high in­ci­dence o f NDM in In­dia and we have been get­ting cases from all over In­dia uni­formly, but it could be higher in fam­i­lies where there is con­san­guin­ity.”

While a ma­jor­ity of chil­dren de­tected with NDM have mu­ta­tions in KCNJ11 and ABCC8 genes, Ishaan’s is the first recorded In­dian case of NDM caused by a mu­ta­tion in PDX1 gene, said his doc­tor, pae­di­atric en­docri­nol­o­gist Dr Ab­hishek Kulka­rni.


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