Study Finds Patients With Metastatic Prostate Cancer Live Notably Longer

Researchers from SWOG Cancer Research Network have significantly extended median survival for patients with hormone-sensitive metastatic prostate cancer. This result comes from a large randomized clinical trial aimed at testing a new treatment for these patients.

The findings of the research were published in the ‘Journal of Clinical Oncology’.

It tested the efficiency of the drug orteronel in these patients, pairing it with androgen deprivation therapy on the investigational arm and comparing that combination to androgen deprivation therapy plus bicalutamide.

Although the study missed the primary endpoint of a 33 per cent improvement in overall survival (OS), it also showed an unprecedented median OS of 70 months in the control arm, the highest ever reported for these patients on a non-intensified androgen deprivation therapy arm. This OS is a 24-month improvement over results reported in 2013 from the SWOG-9346 trial, which enrolled a nearly identical proportion of patients with extensive disease.

The researchers conclude that the primary reason for this extended survival compared to previous studies is the life-prolonging additional treatments patients received after they completed the S1216 trial.

Some 77 per cent of control arm patients whose cancer progressed went on to get additional life-prolonging treatment after finishing the trial therapy, compared to 61 per cent in the orteronel arm.

“We are seeing the benefit of the advancements made in advanced prostate cancer therapy in the last decade, resulting in unprecedented improvements in survival of men with advanced prostate cancer in general, which is great news for our patients,” said study lead author Neeraj Agarwal, MD, a SWOG investigator with the Huntsman Cancer Institute at the University of Utah.