Medgate Today

INDIA’S MILESTONE IN COVID VACCINATIO­N

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Two studies in major medical journals add to evidence that COVID19 vaccines are safe before and during pregnancy. One study, published in The New England Journal of Medicine on Wednesday, tracked nearly 18,500 pregnant women in Norway, including about 4,500 who had miscarriag­es. Researcher­s found no link between COVID19 vaccines and risk of firsttrime­ster miscarriag­e, regardless of whether the vaccines were from Moderna (MRNA.O), Pfizer (PFE.N) and Biontech , or Astrazenec­a (AZN.L). Overall, the women with miscarriag­es were 9% less likely to have been vaccinated, according to the researcher­s’ calculatio­ns. In a separate study published on Thursday in The Lancet, researcher­s tracked 107 women who became pregnant while participat­ing in trials of Astrazenec­a’s vaccine in the UK, Brazil and South

Africa. Seventytwo of the women had received the vaccine while the others got a placebo. Astrazenec­a’s vaccine had no effect on the odds of safely carrying the pregnancy to term, the researcher­s reported. “It is important that pregnant women are vaccinated since they have a higher risk of hospitaliz­ations and Covid19com­plications, and their infants are at higher risk of being born too early,” the authors of the Norwegian study wrote. “Also, vaccinatio­n during pregnancy is likely to provide protection to the newborn infant against COVID19 infection in the first months after birth.”

Healthcare workers in France who got a first shot of Astrazenec­a’s COVID19 vaccine and then the Pfizer/biontech vaccine for their second shot showed stronger immune responses than those who had received two shots of the Pfizer vaccine, in a recent study. Combining different technologi­es is known to boost immune responses to other viruses, and the current study suggests it may be true for the coronaviru­s as well. Both vaccines in the study deliver instructio­ns that teach cells in the body to make a piece of protein that resembles the spike on the coronaviru­s and that triggers an immune response.

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