Ray of hope for women suffering from breast cancer
Indian scientist Mishra proves cancer cells migration, invasion can be checked
Dr Sandip Kumar Mishra, a senior scientist working at the Institute of Life Sciences ( ILS), Bhubaneswar, has “conclusively” proved that cancer cells migration and invasion can be restricted as well as induced apoptosis ( programmed cell death) can also be controlled by Artemisinin in estrogen receptor positive ( ER- positive) breast cancer cells.
This finding will largely help women suffering from ER- positive breast cancer.
Estrogen receptors ( ERs) are a group of proteins found inside cells.
Artemisinin is commonly known for its potent anti- malarial activities. It is also known as qinghao su ( Chinese name), and its derivatives extracted from its flowers and leave are a group of drugs used against malaria.
Dr Mishra, head molecular oncology lab in the department of cancer biology at Institute of Life Sciences ( ILS), Bhubaneswar, and his team has shown that the growth of estrogen receptor positive breast cancer can also be inhibited by Artemisinin.
However, in- vivo and invitro studies show its antitumor properties, makes it a possible potent drug candidate for study with regard to estrogen receptor alpha and beta positive breast cancer.
“For general understanding, Artemisinin, is isolated from the plant, commonly known as sweet wormwood, ( botanical name – ‘ Artemisia annua’). It is a herb species which is being used as a Chinese traditional medicine. Chemically it is a sesquiterpene lactone which contains an unusual peroxide bridge,” says Dr Mishra.
Explaining further on the subject, the scientist says the studies of mechanisms of cell movement can be understood by knowing the involvement of genes vis- a- vis effect of a drug.
Although cytotoxicity and anti- proliferative activity of Artemisinin is kind of known, the genes participating in its antimigratory and reduced invasive effect are not well studied.
◗ Dr Mishra and his team has shown that the growth of estrogen receptor positive breast cancer can also be inhibited by Artemisinin