Baby- wipes can trigger food allergies in infants

Washington, April 8: Baby wipes can trigger the ideal mix of conditions that lead to the development of food allergies in infants, a study has found.

The factors contributing to food allergy include the genetics that alter skin absorbency, use of infant cleansing wipes that leave soap on the skin, skin exposure to allergens in dust and skin exposure to food from those providing infant care.

Food allergy is triggered when these factors occur together, researchers said.

“This is a recipe for developing food allergy. It’s a major advance in our understanding of how food allergy starts early in life,” said Joan Cook- Mills, a professor at Northwestern University in the US.

Factors leading to food allergy can be modified in the home environment, Cook- Mills said.

“Reduce baby’s skin exposure to the food allergens by washing your hands before handling the baby,” Cook- Mills said.

“Limit use of infant wipes that leave soap on the skin. Rinse soap off with water like we used to do years ago,” she said.

Cook- Mills made the discovery by using clinical evidence about food allergy in humans, the effects of food allergen and environmental allergen exposures and neonatal mice with genetic mutations that occur in humans.

Clinical evidence shows up to 35 per cent of children with food allergies have atopic dermatitis and much of that is explained by at least three different gene mutations that reduce the skin barrier.

Cook- Mills used a neonatal mouse model with skin barrier mutations and tried exposing its skin to food allergens like peanuts. The peanuts alone had no effect.

Babies are exposed to environmental allergens in dust in a home.

“They may not be eating food allergens as a newborn, but they are getting them on their skin. Say a sibling with peanut butter on her face kisses the baby. Or a parent is preparing food with peanuts and then handles the baby,” she said.

The top skin layer is made of fats, and the soap in the wipes disrupts that barrier, Cook- Mills said.

Skin problems that occur with skin barrier mutations may not be visible until long after a food allergy has already started.

The neonatal mice with the mutations had normalappearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

After the neonatal mice received three to four skin exposures of food and dust allergens for 40 minutes during a two- week period, they were given egg or peanut by mouth.

The mice had allergic reactions at the site of skin exposure, allergic reactions in the intestine, and the severe allergic food reaction of anaphylaxis that is measured by decreased temperature.

A skin barrier dysfunction was necessary for food allergy to develop in the mice, but there is a continuum of skin dysfunction with eczema or atopic dermatitis, which in its mildest form may simply appear to be dry skin.