‘ New DNA vaccine against Ebola safe’
Washington, Oct. 13: Scientists, including one of Indian- origin, have developed a novel synthetic DNA vaccine against Ebola, which they say is safe and offers a long- term protection from the virus.
Using a unique approach, researchers at the Wistar Institute in the US, designed optimised synthetic DNA vaccine candidates targeting a virus surface protein called glycoprotein.
They demonstrated efficacy of the novel vaccine candidates and durability of the immune responses in animal models.
Results, published in the Journal of Infectious Diseases, showed strong immune responses one year after the last dose, supporting the long- term immunogenicity of the vaccine — a particularly challenging area for Ebola vaccines.
“The success of intradermal delivery of a low- dose regimen is very encouraging. The ultimate goal of our work is to create effective and safe vaccines that are optimised for field use in at- risk areas,” said Ami Patel from the Wistar Institute. The researchers optimised a shorter, dose- sparing, immunisation regimen and simplified vaccine administration directly into the skin. This approach induced rapid immunity from virus.