‘ New DNA vac­cine against Ebola safe’

The Asian Age - - Science + Health -

Wash­ing­ton, Oct. 13: Sci­en­tists, in­clud­ing one of In­dian- ori­gin, have de­vel­oped a novel syn­thetic DNA vac­cine against Ebola, which they say is safe and of­fers a long- term pro­tec­tion from the virus.

Us­ing a unique ap­proach, re­searchers at the Wis­tar In­sti­tute in the US, de­signed op­ti­mised syn­thetic DNA vac­cine can­di­dates tar­get­ing a virus sur­face pro­tein called gly­co­pro­tein.

They demon­strated ef­fi­cacy of the novel vac­cine can­di­dates and dura­bil­ity of the im­mune re­sponses in an­i­mal mod­els.

Re­sults, pub­lished in the Jour­nal of In­fec­tious Dis­eases, showed strong im­mune re­sponses one year af­ter the last dose, sup­port­ing the long- term im­muno­genic­ity of the vac­cine — a par­tic­u­larly chal­leng­ing area for Ebola vac­cines.

“The suc­cess of in­tra­der­mal de­liv­ery of a low- dose reg­i­men is very en­cour­ag­ing. The ul­ti­mate goal of our work is to cre­ate ef­fec­tive and safe vac­cines that are op­ti­mised for field use in at- risk ar­eas,” said Ami Pa­tel from the Wis­tar In­sti­tute. The re­searchers op­ti­mised a shorter, dose- spar­ing, im­mu­ni­sa­tion reg­i­men and sim­pli­fied vac­cine ad­min­is­tra­tion di­rectly into the skin. This ap­proach in­duced rapid im­mu­nity from virus.

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