Mouse sperm on ISS produces 168 offspring

Researchers wanted to know if radiation damages reproductive cell DNA

Washington, June 12: Turns out the comic books were wrong.

Japanese researchers found mouse sperm exposed to high levels of cosmic radiation for nearly six years produced a large brood of healthy, unremarkable “space pups.” Their study was published Friday in Science Advances — which noted no signs so far of Mousezillas or rodent Hulks.

The sperm was stored in the International Space

Station in freeze-dried form. Once brought back to Earth and rehydrated, it resulted in the birth of 168 young, free of genetic defects. Developmental biologist and lead author Teruhiko Wakayama said on Thursday that there was little difference between mice fertilised by space sperm and sperm that had remained confined to our planet.

“All pups had normal appearance,” he said, and when researchers examined their genes “no abnormalities were found.” In 2013, Wakayama and colleagues at the University of Yamanashi in Japan launched three boxes, each containing 48 ampoules of freeze-dried sperm, to the ISS for the long-term study. They wanted to determine whether long term exposure to radiation in space would damage DNA in reproductive cells or pass mutations along to offspring.

That could be a problem for our own species in future space exploration and colonization missions.

Batches were returned to Earth for fertilisation after the first nine months, then after two years, and finally after six years, leading to hundreds of births. Freezedried sperm was selected for the experiment because it can be preserved at room temperature, rather than needing a freezer.

The ampoules were also small and very light, about the size of a small pencil, further cutting launch costs. When the space mice reached adulthood, they were randomly mated and the next generation appeared normal as well.

Wakayama, now director for Advanced Biotechnology Center at the University of Yamanashi, said he had been inspired by the science fiction of Heinlein and Asimov and once wanted to be an astronaut.

Though he settled on becoming a scientist, the sense of wonder and whimsy about space exploration never left him.

“In the future, when the time comes to migrate to other planets, we will need to mantain the diversity of genetic resources, not only for humans but also for pets and domestic animals,” Wakayama and colleagues wrote in their paper.

“For cost and safety reasons, it is likely that stored germ cells will be transported by spaceships rather than by living animals.” Getting to other planets means leaving the safety of Earth’s protective atmosphere and magnetic field — which also extends to the ISS.