Insulin pill for diabetics may replace shots
Innovative new design consists of biodegradable capsule that injects the hormone directly into the stomach wall
BOSTON: Scientists have developed a drug capsule that could be used to deliver oral doses of insulin, paving the way for replacing the painful injections that diabetics have to give themselves every day. About the size of a blueberry, the capsule contains a small needle made of compressed insulin, which is injected after the capsule reaches the stomach. In tests in animals, the researchers showed that they could deliver enough insulin to lower blood sugar to levels comparable to those produced by injections given through skin. The study, published in Science, also demonstrated that the device can be adapted to deliver other protein drugs. “We are really hopeful that this new type of capsule could someday help diabetic patients and perhaps anyone who requires therapies that can now only be given by injection or infusion,” said Robert Langer, from the Massachusetts Institute of Technology (MIT). The tip of the needle is made of nearly 100 per cent compressed, freeze-dried insulin, using the same process used to form tablets of medicine. The shaft of the needle, which does not enter the stomach wall, is made from another biodegradable material. Within the capsule, the needle is attached to a compressed spring that is held in place by a disk made of sugar. When the capsule is swallowed, water in the stomach dissolves the sugar disk, releasing the spring and injecting the needle into the stomach wall. The stomach wall has no pain receptors, so the researchers believe that patients would not be able to feel the injection. To ensure that the drug is injected into the stomach wall, the researchers designed their system so that no matter how the capsule lands in the stomach, it can orient itself so the needle is in contact with the lining of the stomach. “As soon as you take it, you want the system to self-right so that you can ensure contact with the tissue,” said Giovanni Traverso, an assistant professor at Brigham and Women’s Hospital at Harvard Medical School in the US. Once the tip of the needle is injected into the stomach wall, the insulin dissolves at a rate that can be controlled by the researchers as the capsule is prepared. In tests in pigs, the researchers showed that they could successfully deliver up to 300 micrograms of insulin. More recently, they have been able to increase the dose to 5 milligrams, which is comparable to the amount that a patient with type 2 diabetes would need to inject. “Our motivation is to make it easier for patients to take medication, particularly medications that require an injection,” Traverso said.